Literature DB >> 7543987

Altered expression of transforming growth factor-beta in Alzheimer's disease.

K C Flanders1, C F Lippa, T W Smith, D A Pollen, M B Sporn.   

Abstract

We compared immunohistochemical expression of the transforming growth factor-betas (TGF-beta 1, TGF-beta 2, and TGF-beta 3) using brain tissue from patients with nondominantly inherited Alzheimer's disease (NDAD) (n = 9), autosomal dominantly inherited Alzheimer's disease with linkage to 14q24.3 (FAD-14) (n = 4), and cognitively normal controls (n = 10) to determine whether their pathologic changes are associated with an altered distribution of the TGF-betas. We found increased expression of TGF-beta 2 in large, tangle-bearing neurons with widespread staining of glia in NDAD and FAD-14 patients compared with control cases. This result was confirmed with sandwich ELISA assays of brain tissue, which showed TGF-beta 2 levels in AD and NDAD to average 3.2 times the average level of control cases. Despite proximity of TGF-beta 1 and TGF-beta 3 to the sites of susceptibility loci on chromosomes 19 and 14, we did not find that TGF-beta 1 and TGF-beta 3 were selectively altered in any AD subtypes. However, selective induction of TGF-beta 2 may occur in NDAD and FAD-14.

Entities:  

Mesh：

Substances：

Year:  1995        PMID： 7543987     DOI： 10.1212/wnl.45.8.1561

Source DB:  PubMed          Journal:  Neurology        ISSN： 0028-3878            Impact factor:   9.910


  35 in total

1.  Chronic overproduction of transforming growth factor-beta1 by astrocytes promotes Alzheimer's disease-like microvascular degeneration in transgenic mice.

Authors:  T Wyss-Coray; C Lin; D A Sanan; L Mucke; E Masliah
Journal:  Am J Pathol       Date:  2000-01       Impact factor: 4.307

2.  Staging of cytoskeletal and beta-amyloid changes in human isocortex reveals biphasic synaptic protein response during progression of Alzheimer's disease.

Authors:  E B Mukaetova-Ladinska; F Garcia-Siera; J Hurt; H J Gertz; J H Xuereb; R Hills; C Brayne; F A Huppert; E S Paykel; M McGee; R Jakes; W G Honer; C R Harrington; C M Wischik
Journal:  Am J Pathol       Date:  2000-08       Impact factor: 4.307

Review 3.  Potential importance of B cells in aging and aging-associated neurodegenerative diseases.

Authors:  Arya Biragyn; Maria Aliseychik; Evgeny Rogaev
Journal:  Semin Immunopathol       Date:  2017-01-12       Impact factor: 9.623

4.  TGF beta2-induced changes in LRP-1/T beta R-V and the impact on lysosomal A beta uptake and neurotoxicity.

Authors:  Pirooz Eslami; Ming F Johnson; Ellen Terzakaryan; Carolyn Chew; Marni E Harris-White
Journal:  Brain Res       Date:  2008-09-10       Impact factor: 3.252

5.  Effects of transforming growth factor-beta (isoforms 1-3) on amyloid-beta deposition, inflammation, and cell targeting in organotypic hippocampal slice cultures.

Authors:  M E Harris-White; T Chu; Z Balverde; J J Sigel; K C Flanders; S A Frautschy
Journal:  J Neurosci       Date:  1998-12-15       Impact factor: 6.167

Review 6.  Neural-immune interactions in health and disease.

Authors:  E M Sternberg
Journal:  J Clin Invest       Date:  1997-12-01       Impact factor: 14.808

7.  TGF-beta2 alters the characteristics of the neuromuscular junction by regulating presynaptic quantal size.

Authors:  Sitt Wai Fong; Ian S McLennan; Andrew McIntyre; Jayne Reid; Kathleen I J Shennan; Guy S Bewick
Journal:  Proc Natl Acad Sci U S A       Date:  2010-07-12       Impact factor: 11.205

Review 8.  Inflammation and Alzheimer's disease.

Authors:  H Akiyama; S Barger; S Barnum; B Bradt; J Bauer; G M Cole; N R Cooper; P Eikelenboom; M Emmerling; B L Fiebich; C E Finch; S Frautschy; W S Griffin; H Hampel; M Hull; G Landreth; L Lue; R Mrak; I R Mackenzie; P L McGeer; M K O'Banion; J Pachter; G Pasinetti; C Plata-Salaman; J Rogers; R Rydel; Y Shen; W Streit; R Strohmeyer; I Tooyoma; F L Van Muiswinkel; R Veerhuis; D Walker; S Webster; B Wegrzyniak; G Wenk; T Wyss-Coray
Journal:  Neurobiol Aging       Date:  2000 May-Jun       Impact factor: 4.673

Review 9.  Transforming growth factor-beta and ischemic brain injury.

Authors:  Alain Buisson; Sylvain Lesne; Fabian Docagne; Carine Ali; Olivier Nicole; Eric T MacKenzie; Denis Vivien
Journal:  Cell Mol Neurobiol       Date:  2003-10       Impact factor: 5.046

10.  Sp1 and Smad transcription factors co-operate to mediate TGF-beta-dependent activation of amyloid-beta precursor protein gene transcription.

Authors:  Fabian Docagne; Cecilia Gabriel; Nathalie Lebeurrier; Sylvain Lesné; Yannick Hommet; Laurent Plawinski; Eric T Mackenzie; Denis Vivien
Journal:  Biochem J       Date:  2004-10-15       Impact factor: 3.857
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.