Literature DB >> 7543751

The chloride effect in the human embryonic haemoglobins.

O Hofmann1, G Carrucan, N Robson, T Brittain.   

Abstract

The interactions of the three human embryonic haemoglobins with chloride ions have been investigated. Each of the three embryonic haemoglobins exhibits a unique pattern of oxygen-affinity-dependence on chloride ion concentration. Human embryonic haemoglobin Portland (zeta 2 gamma 2) is found to be completely insensitive to chloride ion concentration. Haemoglobin Gower I (zeta 2 gamma 2) shows a small concentration dependence, whilst haemoglobin Gower II (alpha 2 epsilon 2) exhibits a dependence approaching that of the adult protein. The degree of co-operativity for each protein is essentially chloride concentration independent. The chloride-dependent and -independent components of the alkaline Bohr effects have been measured for each of the embryonic haemoglobins and compared with that of the adult protein. Both the chloride-binding data and the Bohr effect have been analysed in terms of the recently developed allosteric model proposed by Perutz [Perutz, Fermi, Poyart, Pagnier and Kister (1993) J. Mol. Biol. 233, 536-545].

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Year:  1995        PMID： 7543751      PMCID： PMC1135724          DOI： 10.1042/bj3090959

Source DB:  PubMed          Journal:  Biochem J        ISSN： 0264-6021            Impact factor:   3.857


  15 in total

1.  STUDIES ON THE RELATIONS BETWEEN MOLECULAR AND FUNCTIONAL PROPERTIES OF HEMOGLOBIN. IV. THE BOHR EFFECT IN HUMAN HEMOGLOBIN MEASURED BY PROTON BINDING.

Authors:  E ANTONINI; J WYMAN; M BRUNORI; E BUCCI; C FRONTICELLI; A ROSSI-FANELLI
Journal:  J Biol Chem       Date:  1963-09       Impact factor: 5.157

2.  X-ray diffraction and solution studies of specifically carbamylated human hemoglobin A. Evidence for the location of a proton- and oxygen-linked chloride binding site at valine 1 alpha.

Authors:  S O'Donnell; R Mandaro; T M Schuster; A Arnone
Journal:  J Biol Chem       Date:  1979-12-10       Impact factor: 5.157

3.  High-resolution X-ray study of deoxyhemoglobin Rothschild 37 beta Trp----Arg: a mutation that creates an intersubunit chloride-binding site.

Authors:  J S Kavanaugh; P H Rogers; D A Case; A Arnone
Journal:  Biochemistry       Date:  1992-04-28       Impact factor: 3.162

4.  Hemoglobin providence. Functional consequences of two alterations of the 2,3-diphosphoglycerate binding site at position beta 82.

Authors:  J Bonaventura; C Bonaventura; B Sullivan; G Ferruzzi; P R McCurdy; J Fox; W F Moo-Penn
Journal:  J Biol Chem       Date:  1976-12-10       Impact factor: 5.157

5.  A mutagenic study of the allosteric linkage of His(HC3)146 beta in haemoglobin.

Authors:  D T Shih; B F Luisi; G Miyazaki; M F Perutz; K Nagai
Journal:  J Mol Biol       Date:  1993-04-20       Impact factor: 5.469

6.  A novel allosteric mechanism in haemoglobin. Structure of bovine deoxyhaemoglobin, absence of specific chloride-binding sites and origin of the chloride-linked Bohr effect in bovine and human haemoglobin.

Authors:  M F Perutz; G Fermi; C Poyart; J Pagnier; J Kister
Journal:  J Mol Biol       Date:  1993-10-05       Impact factor: 5.469

7.  Production of human embryonic haemoglobin (Gower II) in a yeast expression system.

Authors:  R M Mould; O M Hofmann; T Brittain
Journal:  Biochem J       Date:  1994-03-15       Impact factor: 3.857

8.  Allosteric modulation of oxygen binding to the three human embryonic haemoglobins.

Authors:  O Hofmann; R Mould; T Brittain
Journal:  Biochem J       Date:  1995-03-01       Impact factor: 3.857

9.  The chloride effect in human haemoglobin. A new kind of allosteric mechanism.

Authors:  M F Perutz; D T Shih; D Williamson
Journal:  J Mol Biol       Date:  1994-06-17       Impact factor: 5.469

10.  Chloride masks effects of opposing positive charges in Hb A and Hb Hinsdale (beta 139 Asn-->Lys) that can modulate cooperativity as well as oxygen affinity.

Authors:  C Bonaventura; M Arumugam; R Cashon; J Bonaventura; W F Moo-Penn
Journal:  J Mol Biol       Date:  1994-06-17       Impact factor: 5.469
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  7 in total

1.  Ligand binding kinetics and dissociation of the human embryonic haemoglobins.

Authors:  O Hofmann; T Brittain
Journal:  Biochem J       Date:  1996-04-01       Impact factor: 3.857

2.  A two-state analysis of co-operative oxygen binding in the three human embryonic haemoglobins.

Authors:  T Brittain; O M Hofmann; N J Watmough; C Greenwood; R E Weber
Journal:  Biochem J       Date:  1997-09-01       Impact factor: 3.857

3.  Some effects of post-translational N-terminal acetylation of the human embryonic zeta globin protein.

Authors:  A Scheepens; R Mould; O Hofmann; T Brittain
Journal:  Biochem J       Date:  1995-09-01       Impact factor: 3.857

4.  Molecular and physicochemical characterization of hemoglobin from the high-altitude Taiwanese brown-toothed shrew (Episoriculus fumidus).

Authors:  Kevin L Campbell; Anthony V Signore; Masashi Harada; Roy E Weber
Journal:  J Comp Physiol B       Date:  2012-04-06       Impact factor: 2.200

5.  Genetic differences in hemoglobin function between highland and lowland deer mice.

Authors:  Jay F Storz; Amy M Runck; Hideaki Moriyama; Roy E Weber; Angela Fago
Journal:  J Exp Biol       Date:  2010-08-01       Impact factor: 3.312

6.  Changes in hemoglobin function and isoform expression during embryonic development in the American alligator, Alligator mississippiensis.

Authors:  Naim M Bautista; Elin E Petersen; Rasmus J Jensen; Chandrasekhar Natarajan; Jay F Storz; Dane A Crossley; Angela Fago
Journal:  Am J Physiol Regul Integr Comp Physiol       Date:  2021-10-27       Impact factor: 3.619

7.  Lack of conventional oxygen-linked proton and anion binding sites does not impair allosteric regulation of oxygen binding in dwarf caiman hemoglobin.

Authors:  Roy E Weber; Angela Fago; Hans Malte; Jay F Storz; Thomas A Gorr
Journal:  Am J Physiol Regul Integr Comp Physiol       Date:  2013-05-29       Impact factor: 3.619
  7 in total

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