PURPOSE: The significance of prostate specific antigen (PSA) in the mass screening for prostate cancer was investigated. MATERIALS AND METHODS: A total of 4,375 PSA, digital rectal and transrectal ultrasonographic examinations was performed on 3,526 subjects. RESULTS: Among the 3 modalities, PSA had the highest sensitivity (80.4%) and positive predictive value (45.1%). We established age-specific reference PSA ranges for normal Japanese men, and demonstrated the significance of PSA density and PSA velocity. CONCLUSIONS: The significance of PSA as a prostate cancer screening modality should be evaluated across multiple age ranges and in combination with previous PSA data and/or prostate volume.
PURPOSE: The significance of prostate specific antigen (PSA) in the mass screening for prostate cancer was investigated. MATERIALS AND METHODS: A total of 4,375 PSA, digital rectal and transrectal ultrasonographic examinations was performed on 3,526 subjects. RESULTS: Among the 3 modalities, PSA had the highest sensitivity (80.4%) and positive predictive value (45.1%). We established age-specific reference PSA ranges for normal Japanese men, and demonstrated the significance of PSA density and PSA velocity. CONCLUSIONS: The significance of PSA as a prostate cancer screening modality should be evaluated across multiple age ranges and in combination with previous PSA data and/or prostate volume.
Authors: Oseremen I Aisuodionoe-Shadrach; Sefiu B Eniola; Maxwell M Nwegbu; Hadijat O Kolade-Yunusa; Oriaku O Okereke; Thairu Yunusa Journal: Cancer Control Date: 2022 Jan-Dec Impact factor: 3.302
Authors: N Pashayan; S W Duffy; P Pharoah; D Greenberg; J Donovan; R M Martin; F Hamdy; D E Neal Journal: Br J Cancer Date: 2009-03-17 Impact factor: 7.640