Literature DB >> 7543590

Induction of macrophage procoagulant activity by murine hepatitis virus strain 3: role of tyrosine phosphorylation.

A P Dackiw1, K Zakrzewski, A B Nathens, P Y Cheung, R Fingerote, G A Levy, O D Rotstein.   

Abstract

The induction of a unique macrophage procoagulant molecule by murine hepatitis virus strain 3 correlates with the severity of viral hepatitis. The role of tyrosine phosphorylation in the signalling pathway leading to procoagulant expression was studied. Murine hepatitis virus strain 3 initiated a rapid increase in phosphotyrosine accumulation. Tyrosine kinase inhibition precluded this increase and abrogated expression of the virus-induced procoagulant mouse fibrinogen-like protein (musfiblp) gene. These findings suggest that manipulation of this signalling pathway in vivo might represent a novel approach to treating this disease.

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Year:  1995        PMID： 7543590      PMCID： PMC189451     

Source DB:  PubMed          Journal:  J Virol        ISSN： 0022-538X            Impact factor:   5.103


  30 in total

1.  The kinetics and metabolic requirements for direct lymphocyte induction of human procoagulant monokines by bacterial lipopolysaccharide.

Authors:  G A Levy; B S Schwartz; T S Edgington
Journal:  J Immunol       Date:  1981-07       Impact factor: 5.422

2.  Detection and quantification of phosphotyrosine in proteins.

Authors:  J A Cooper; B M Sefton; T Hunter
Journal:  Methods Enzymol       Date:  1983       Impact factor: 1.600

3.  The sequences of an expressed rat alpha-tubulin gene and a pseudogene with an inserted repetitive element.

Authors:  I Lemischka; P A Sharp
Journal:  Nature       Date:  1982-11-25       Impact factor: 49.962

4.  Susceptibility/resistance to mouse hepatitis virus strain 3 and macrophage procoagulant activity are genetically linked and controlled by two non-H-2-linked genes.

Authors:  V J Dindzans; E Skamene; G A Levy
Journal:  J Immunol       Date:  1986-10-01       Impact factor: 5.422

5.  Cloning of the mouse hepatitis virus (MHV) receptor: expression in human and hamster cell lines confers susceptibility to MHV.

Authors:  G S Dveksler; M N Pensiero; C B Cardellichio; R K Williams; G S Jiang; K V Holmes; C W Dieffenbach
Journal:  J Virol       Date:  1991-12       Impact factor: 5.103

6.  Disparate mechanisms of induction of procoagulant activity by live and inactivated bacteria and viruses.

Authors:  S B Sinclair; O D Rotstein; G A Levy
Journal:  Infect Immun       Date:  1990-06       Impact factor: 3.441

7.  Genistein, a specific inhibitor of tyrosine-specific protein kinases.

Authors:  T Akiyama; J Ishida; S Nakagawa; H Ogawara; S Watanabe; N Itoh; M Shibuya; Y Fukami
Journal:  J Biol Chem       Date:  1987-04-25       Impact factor: 5.157

8.  16, 16 Dimethyl prostaglandin E2 prevents the development of fulminant hepatitis and blocks the induction of monocyte/macrophage procoagulant activity after murine hepatitis virus strain 3 infection.

Authors:  M Abecassis; J A Falk; L Makowka; V J Dindzans; R E Falk; G A Levy
Journal:  J Clin Invest       Date:  1987-09       Impact factor: 14.808

9.  Carcinoembryonic antigens: alternative splicing accounts for the multiple mRNAs that code for novel members of the carcinoembryonic antigen family.

Authors:  T R Barnett; A Kretschmer; D A Austen; S J Goebel; J T Hart; J J Elting; M E Kamarck
Journal:  J Cell Biol       Date:  1989-02       Impact factor: 10.539

10.  Induction of monocyte procoagulant activity by murine hepatitis virus type 3 parallels disease susceptibility in mice.

Authors:  G A Levy; J L Leibowitz; T S Edgington
Journal:  J Exp Med       Date:  1981-10-01       Impact factor: 14.307
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  2 in total

1.  Proteasome inhibition in vivo promotes survival in a lethal murine model of severe acute respiratory syndrome.

Authors:  Xue-Zhong Ma; Agata Bartczak; Jianhua Zhang; Ramzi Khattar; Limin Chen; Ming Feng Liu; Aled Edwards; Gary Levy; Ian D McGilvray
Journal:  J Virol       Date:  2010-09-22       Impact factor: 5.103

Review 2.  The molecular biology of coronaviruses.

Authors:  M M Lai; D Cavanagh
Journal:  Adv Virus Res       Date:  1997       Impact factor: 9.937
  2 in total

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