Literature DB >> 7543589

Cyclophilin binding to the human immunodeficiency virus type 1 Gag polyprotein is mimicked by an anti-cyclosporine antibody.

E K Franke1, B X Chen, I Tatsis, A Diamanduros, B F Erlanger, J Luban.   

Abstract

Human immunodeficiency virus type 1 is unique among retroviruses in that infectivity requires specific incorporation into virions of the cellular protein cyclophilin A through interactions with the Gag polyprotein. Here we show that monoclonal antibody B11 1.4, which recognizes a cyclophilin-binding epitope on cyclosporine, detects denatured or native human immunodeficiency virus type 1 capsid. B11 1.4 does not recognize the capsids of other retroviruses, and binding is inhibited by cyclosporine or by cyclophilin A.

Entities:  

Mesh：

Substances：

Year:  1995        PMID： 7543589      PMCID： PMC189450     

Source DB:  PubMed          Journal:  J Virol        ISSN： 0022-538X            Impact factor:   5.103


  19 in total

1.  Binding of human immunodeficiency virus type 1 (HIV-1) RNA to recombinant HIV-1 gag polyprotein.

Authors:  J Luban; S P Goff
Journal:  J Virol       Date:  1991-06       Impact factor: 5.103

2.  Rusting of the lock and key model for protein-ligand binding.

Authors:  W L Jorgensen
Journal:  Science       Date:  1991-11-15       Impact factor: 47.728

3.  Receptor-induced conformation change of the immunosuppressant cyclosporin A.

Authors:  K Wüthrich; B von Freyberg; C Weber; G Wider; R Traber; H Widmer; W Braun
Journal:  Science       Date:  1991-11-15       Impact factor: 47.728

Review 4.  The mechanism of protein folding. Implications of in vitro refolding models for de novo protein folding and translocation in the cell.

Authors:  G Fischer; F X Schmid
Journal:  Biochemistry       Date:  1990-03-06       Impact factor: 3.162

5.  The NMR structure of cyclosporin A bound to cyclophilin in aqueous solution.

Authors:  C Weber; G Wider; B von Freyberg; R Traber; W Braun; H Widmer; K Wüthrich
Journal:  Biochemistry       Date:  1991-07-02       Impact factor: 3.162

6.  NMR studies of [U-13C]cyclosporin A bound to cyclophilin: bound conformation and portions of cyclosporin involved in binding.

Authors:  S W Fesik; R T Gampe; H L Eaton; G Gemmecker; E T Olejniczak; P Neri; T F Holzman; D A Egan; R Edalji; R Simmer
Journal:  Biochemistry       Date:  1991-07-02       Impact factor: 3.162

7.  Cyclophilin: a specific cytosolic binding protein for cyclosporin A.

Authors:  R E Handschumacher; M W Harding; J Rice; R J Drugge; D W Speicher
Journal:  Science       Date:  1984-11-02       Impact factor: 47.728

8.  Novel monoclonal antibodies to cyclosporine A: characterization and epitope mapping with cyclosporine analogs and cyclophilin.

Authors:  N A Cacalano; R Aggarwal; V F Quesniaux; W L Cleveland; B F Erlanger
Journal:  Mol Immunol       Date:  1992-01       Impact factor: 4.407

9.  The cyclophilin homolog ninaA is required in the secretory pathway.

Authors:  N J Colley; E K Baker; M A Stamnes; C S Zuker
Journal:  Cell       Date:  1991-10-18       Impact factor: 41.582

10.  Inhibition of human immunodeficiency virus type 1 replication by SDZ NIM 811, a nonimmunosuppressive cyclosporine analog.

Authors:  B Rosenwirth; A Billich; R Datema; P Donatsch; F Hammerschmid; R Harrison; P Hiestand; H Jaksche; P Mayer; P Peichl
Journal:  Antimicrob Agents Chemother       Date:  1994-08       Impact factor: 5.191
View more
  2 in total

1.  Binding of the human immunodeficiency virus type 1 Gag polyprotein to cyclophilin A is mediated by the central region of capsid and requires Gag dimerization.

Authors:  J Colgan; H E Yuan; E K Franke; J Luban
Journal:  J Virol       Date:  1996-07       Impact factor: 5.103

2.  The human immunodeficiency virus type 1 capsid p2 domain confers sensitivity to the cyclophilin-binding drug SDZ NIM 811.

Authors:  T Dorfman; H G Göttlinger
Journal:  J Virol       Date:  1996-09       Impact factor: 5.103
  2 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.