Literature DB >> 7543062

Lipopolysaccharide treatment in vivo induces tissue expression of GTP cyclohydrolase I mRNA.

Y Hattori1, M Oka, K Kasai, N Nakanishi, S I Shimoda.   

Abstract

A significant induction of GTP cyclohydrolase I (GTPCH) mRNA was observed in lung, heart and kidney of rats treated with lipopolysaccharide (LPS; 10 mg/kg i.v.). GTPCH mRNA levels in liver were high even in untreated rats, and remained elevated after LPS treatment. Parallel induction of nitric oxide synthase (NOS) mRNA was observed in these tissues of LPS-treated rats. Our results demonstrate induction of GTPCH mRNA after LPS treatment in vivo and provide molecular evidence for the increased GTPCH activity which may up-regulate NOS activity in vivo.

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Year:  1995        PMID： 7543062     DOI： 10.1016/0014-5793(95)00689-7

Source DB:  PubMed          Journal:  FEBS Lett        ISSN： 0014-5793            Impact factor:   4.124


  6 in total

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Journal:  Biochem J       Date:  2001-04-15       Impact factor: 3.857

Review 5.  Tetrahydrobiopterin, superoxide, and vascular dysfunction.

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Journal:  Free Radic Biol Med       Date:  2009-07-21       Impact factor: 7.376

6.  Tetrahydrobiopterin availability, nitric oxide metabolism and glutathione status in the hph-1 mouse; implications for the pathogenesis and treatment of tetrahydrobiopterin deficiency states.

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  6 in total

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