Literature DB >> 7542767

Effects of Isoprinosine on Echinococcus multilocularis and E. granulosus metacestodes.

M E Sarciron1, S Walbaum, A F Petavy.   

Abstract

An in vivo study of the effect of Isoprinosine on Echinococcus multilocularis and E. granulosus metacestodes (Cestoda) was performed. Short- and long-term treatments with different doses were tested in experimental hosts: jirds for E. multilocularis and mice for E. granulosus. Modifications in the weight of animals as well as macroscopical and ultrastructural aspects were registered for each animal group. The results obtained showed a considerable ultrastructural alteration in E. multilocularis metacestodes after short-term treatment with the highest dose, and the tissue transplants were negative. In E. granulosus cysts the ultrastructural damage was also very important and its severity increased as the dose was raised. For the two parasites, the macroscopical aspect and weight of the lesions were profoundly changed.

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Year:  1995        PMID： 7542767     DOI： 10.1007/bf00931540

Source DB:  PubMed          Journal:  Parasitol Res        ISSN： 0932-0113            Impact factor:   2.289


  33 in total

1.  Prevalence of human alveolar echinococcosis in Hokkaido as evaluated by western blotting.

Authors:  K Furuya; M Nishizuka; H Honma; M Kumagai; N Sato; M Takahashi; J Uchino
Journal:  Jpn J Med Sci Biol       Date:  1990-04

2.  Life cycles of Echinococcus multilocularis in relation to human infection.

Authors:  A F Petavy; S Deblock; S Walbaum
Journal:  J Parasitol       Date:  1991-02       Impact factor: 1.276

3.  Rapid recovery of Echinococcus granulosus following 'successful' albendazole therapy in a gerbil model.

Authors:  D H Taylor; K S Richards; D L Morris
Journal:  J Helminthol       Date:  1989-12       Impact factor: 2.170

4.  Potential anti-echinococcal activity of alkylaminoethers.

Authors:  T Duriez; P Depreux; P Thuillier; D Afchain; A Marcincal; S Deblock
Journal:  Parasitol Res       Date:  1992       Impact factor: 2.289

5.  Factors influencing the response to chemotherapy in human cystic echinococcosis.

Authors:  T Todorov; G Mechkov; K Vutova; P Georgiev; I Lazarova; Z Tonchev; G Nedelkov
Journal:  Bull World Health Organ       Date:  1992       Impact factor: 9.408

6.  The efficacy of inosine pranobex in preventing the acquired immunodeficiency syndrome in patients with human immunodeficiency virus infection. The Scandinavian Isoprinosine Study Group.

Authors:  C Pedersen; E Sandström; C S Petersen; G Norkrans; J Gerstoft; A Karlsson; K C Christensen; C Håkansson; P O Pehrson; J O Nielsen
Journal:  N Engl J Med       Date:  1990-06-21       Impact factor: 91.245

7.  Echinococcus multilocularis metacestodes: biochemical and ultrastructural investigations on the effect of isatin (2-3 indoline dione) in vivo.

Authors:  I Delabre-Defayolle; M E Sarciron; P Audin; C Gabrion; T Duriez; J Paris; A F Petavy
Journal:  J Antimicrob Chemother       Date:  1989-02       Impact factor: 5.790

8.  Chemotherapy of alveolar echinococcosis. Comparison of plasma mebendazole concentrations in animals and man.

Authors:  F Witassek; B Burkhardt; J Eckert; J Bircher
Journal:  Eur J Clin Pharmacol       Date:  1981       Impact factor: 2.953

9.  Alveolar hydatid disease of the liver: a report on thirty-nine surgical cases in eastern Anatolia, Turkey.

Authors:  A Akinoglu; H Demiryurek; C Guzel
Journal:  Am J Trop Med Hyg       Date:  1991-08       Impact factor: 2.345

10.  The efficacy of chemotherapy with mebendazole in human cystic echinococcosis: long-term follow-up of 52 patients.

Authors:  C Bartoloni; A Tricerri; L Guidi; G Gambassi
Journal:  Ann Trop Med Parasitol       Date:  1992-06
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  3 in total

1.  Progress in the pharmacological treatment of human cystic and alveolar echinococcosis: Compounds and therapeutic targets.

Authors:  Mar Siles-Lucas; Adriano Casulli; Roberto Cirilli; David Carmena
Journal:  PLoS Negl Trop Dis       Date:  2018-04-20

Review 2.  Inosine Pranobex: A Key Player in the Game Against a Wide Range of Viral Infections and Non-Infectious Diseases.

Authors:  Jiri Sliva; Chrysoula N Pantzartzi; Martin Votava
Journal:  Adv Ther       Date:  2019-06-05       Impact factor: 3.845

3.  The importance of being parasiticidal… an update on drug development for the treatment of alveolar echinococcosis.

Authors:  Britta Lundström-Stadelmann; Reto Rufener; Dominic Ritler; Raphael Zurbriggen; Andrew Hemphill
Journal:  Food Waterborne Parasitol       Date:  2019-03-14
  3 in total

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