Literature DB >> 7542514

The antiperinuclear factor and antikeratin antibody systems.

P Youinou1, G Serre.   

Abstract

Antiperinuclear factor (APF) and antikeratin antibody (AKA) have long been known to be associated with rheumatoid arthritis. Human buccal mucosa epithelial cells have hitherto been required as the substrate in the APF test, while AKAs are detected on rat esophagus sections, using an indirect immunofluorescence technique. These two autoantibodies proved to be interrelated. Cytoplasmic inclusions in buccal cells have presumptively been termed keratohyalin granules and the APF target antigen colocalizes exactly with that of antiprofilaggrin antibody within the perinuclear organelles. The latter protein has convincingly been identified as the genuine specificity of the so-called AKA.

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Year:  1995        PMID： 7542514     DOI： 10.1159/000237093

Source DB:  PubMed          Journal:  Int Arch Allergy Immunol        ISSN： 1018-2438            Impact factor:   2.749


  8 in total

1.  Serum immunoglobulins and the risk of rheumatoid arthritis.

Authors:  K Aho; M Heliövaara; P Knekt; A Reunanen; A Aromaa; A Leino; P Kurki; R Heikkilä; T Palosuo
Journal:  Ann Rheum Dis       Date:  1997-06       Impact factor: 19.103

2.  Anti-A2/RA33 autoantibodies are directed to the RNA binding region of the A2 protein of the heterogeneous nuclear ribonucleoprotein complex. Differential epitope recognition in rheumatoid arthritis, systemic lupus erythematosus, and mixed connective tissue disease.

Authors:  K Skriner; W H Sommergruber; V Tremmel; I Fischer; A Barta; J S Smolen; G Steiner
Journal:  J Clin Invest       Date:  1997-07-01       Impact factor: 14.808

3.  Anti-perinuclear factor compared with the so called "antikeratin" antibodies and antibodies to human epidermis filaggrin, in the diagnosis of arthritides.

Authors:  C Vincent; F de Keyser; C Masson-Bessière; M Sebbag; E M Veys; G Serre
Journal:  Ann Rheum Dis       Date:  1999-01       Impact factor: 19.103

4.  In the rheumatoid pannus, anti-filaggrin autoantibodies are produced by local plasma cells and constitute a higher proportion of IgG than in synovial fluid and serum.

Authors:  C Masson-Bessière; M Sebbag; J J Durieux; L Nogueira; C Vincent; E Girbal-Neuhauser; R Durroux; A Cantagrel; G Serre
Journal:  Clin Exp Immunol       Date:  2000-03       Impact factor: 4.330

Review 5.  The serological diagnosis of rheumatoid arthritis: antibodies to citrullinated antigens.

Authors:  Karl Egerer; Eugen Feist; Gerd-Rüdiger Burmester
Journal:  Dtsch Arztebl Int       Date:  2009-03-06       Impact factor: 5.594

Review 6.  Auto-antibodies and autoreactive T-cells in rheumatoid arthritis: pathogenetic players and diagnostic tools.

Authors:  Günter Steiner
Journal:  Clin Rev Allergy Immunol       Date:  2007-02       Impact factor: 10.817

Review 7.  Autoantibodies in rheumatoid arthritis and their clinical significance.

Authors:  Günter Steiner; Josef Smolen
Journal:  Arthritis Res       Date:  2002-04-26

Review 8.  Historical observations contributing insights on etiopathogenesis of rheumatoid arthritis and role of rheumatoid factor.

Authors:  Eng M Tan; Josef S Smolen
Journal:  J Exp Med       Date:  2016-09-12       Impact factor: 14.307
  8 in total

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