OBJECTIVE: To study in an optimized design the possible relation between serum levels in weeks 8-14 of human placental lactogen and pregnancy-associated plasma protein A and fetal size at delivery. METHODS: Analysis of data from 93 normal singleton pregnancies. Gestational age was assessed from a sonographic crown-rump length measurement. Serum levels of human placental lactogen and pregnancy-associated plasma protein A were determined by radioimmunoassay, and were expressed in multiples of mean. The relative birth weight was used as an index of fetal growth. RESULTS: Serum levels of human placental lactogen and pregnancy-associated plasma protein A showed a negative correlation to gestational age at delivery (p < 0.01 and p < 0.05, respectively), and there was a positive correlation between the serum level of pregnancy-associated plasma protein A and relative birth weight (p < 0.02). CONCLUSIONS: Higher levels of human placental lactogen and pregnancy-associated plasma protein A predicted earlier delivery, maybe because of better fetal growth, and higher levels of pregnancy-associated plasma protein A predicted better fetal growth.
OBJECTIVE: To study in an optimized design the possible relation between serum levels in weeks 8-14 of human placental lactogen and pregnancy-associated plasma protein A and fetal size at delivery. METHODS: Analysis of data from 93 normal singleton pregnancies. Gestational age was assessed from a sonographic crown-rump length measurement. Serum levels of human placental lactogen and pregnancy-associated plasma protein A were determined by radioimmunoassay, and were expressed in multiples of mean. The relative birth weight was used as an index of fetal growth. RESULTS: Serum levels of human placental lactogen and pregnancy-associated plasma protein A showed a negative correlation to gestational age at delivery (p < 0.01 and p < 0.05, respectively), and there was a positive correlation between the serum level of pregnancy-associated plasma protein A and relative birth weight (p < 0.02). CONCLUSIONS: Higher levels of human placental lactogen and pregnancy-associated plasma protein A predicted earlier delivery, maybe because of better fetal growth, and higher levels of pregnancy-associated plasma protein A predicted better fetal growth.
Authors: Raziel Rojas-Rodriguez; Rachel Ziegler; Tiffany DeSouza; Sana Majid; Aylin S Madore; Nili Amir; Veronica A Pace; Daniel Nachreiner; David Alfego; Jomol Mathew; Katherine Leung; Tiffany A Moore Simas; Silvia Corvera Journal: Sci Transl Med Date: 2020-11-25 Impact factor: 17.956
Authors: Federica Visconti; Paola Quaresima; Eusebio Chiefari; Patrizia Caroleo; Biagio Arcidiacono; Luigi Puccio; Maria Mirabelli; Daniela P Foti; Costantino Di Carlo; Raffaella Vero; Antonio Brunetti Journal: Int J Environ Res Public Health Date: 2019-09-28 Impact factor: 3.390