Literature DB >> 7542425

Ganglioglioma with neurofibrillary tangles (NFTs): neoplastic NFTs share antigenic determinants with NFTs of Alzheimer's disease.

D Soffer1, F Umansky, J E Goldman.   

Abstract

A cerebral ganglioglioma contained abundant neurofibrillary tangles (NFTs) of the paired helical filament (PHF) type. The NFTs in the tumor were argyrophilic and Congo red and thioflavin-S positive. Immunohistochemically, the NFTs were reactive with antibodies to phosphorylated neurofilament protein, PHF/tau and ubiquitin. The demonstration in the neoplasm of abnormally phosphorylated and ubiquitinated cytoskeletal components, similar in morphology and in immunoreactivity to those seen in NFTs of Alzheimer's disease, suggest that similar pathogenetic mechanisms may operate in both conditions.

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Year:  1995        PMID： 7542425     DOI： 10.1007/bf00307651

Source DB:  PubMed          Journal:  Acta Neuropathol        ISSN： 0001-6322            Impact factor:   17.088


  17 in total

1.  Neurofibrillary tangles, granulovacuolar degeneration and argentophilic bodies in a third ventricle tumour.

Authors:  I Janota
Journal:  Acta Neuropathol       Date:  1974       Impact factor: 17.088

2.  Ganglioglioma containing osseous tissue and neurofibrillary tangles.

Authors:  A Hori; R Weiss; T Schaake
Journal:  Arch Pathol Lab Med       Date:  1988-06       Impact factor: 5.534

Review 3.  Neuropathological substrates of Alzheimer's disease and Parkinson's disease.

Authors:  K Jellinger
Journal:  J Neural Transm Suppl       Date:  1987

4.  Ubiquitin is detected in neurofibrillary tangles and senile plaque neurites of Alzheimer disease brains.

Authors:  G Perry; R Friedman; G Shaw; V Chau
Journal:  Proc Natl Acad Sci U S A       Date:  1987-05       Impact factor: 11.205

5.  Structural stability of paired helical filaments requires microtubule-binding domains of tau: a model for self-association.

Authors:  H Ksiezak-Reding; S H Yen
Journal:  Neuron       Date:  1991-05       Impact factor: 17.173

6.  A human ganglioglioma containing paired helical filaments.

Authors:  M A Oberc-Greenwood; P E McKeever; P L Kornblith; B H Smith
Journal:  Hum Pathol       Date:  1984-09       Impact factor: 3.466

7.  The pathology of the neuronal cytoskeleton in Alzheimer's disease.

Authors:  J P Brion
Journal:  Biochim Biophys Acta       Date:  1992-11-10

8.  Monoclonal antibodies to Alzheimer neurofibrillary tangles. 1. Identification of polypeptides.

Authors:  S H Yen; A Crowe; D W Dickson
Journal:  Am J Pathol       Date:  1985-08       Impact factor: 4.307

9.  Alzheimer neurofibrillary tangles in diseases other than senile and presenile dementia.

Authors:  K Wisniewski; G A Jervis; R C Moretz; H M Wisniewski
Journal:  Ann Neurol       Date:  1979-03       Impact factor: 10.422

Review 10.  Altered tau and neurofilament proteins in neuro-degenerative diseases: diagnostic implications for Alzheimer's disease and Lewy body dementias.

Authors:  J Q Trojanowski; M L Schmidt; R W Shin; G T Bramblett; D Rao; V M Lee
Journal:  Brain Pathol       Date:  1993-01       Impact factor: 6.508
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  3 in total

1.  Classification of diseases with accumulation of Tau protein.

Authors:  Gabor G Kovacs; Bernardino Ghetti; Michel Goedert
Journal:  Neuropathol Appl Neurobiol       Date:  2022-02-09       Impact factor: 6.250

2.  Enhanced expression of autophagy-related p62 without increased deposits of neurodegeneration-associated proteins in glioblastoma and surrounding tissue - An autopsy-based study.

Authors:  Sigrid Klotz; Gerda Ricken; Matthias Preusser; Karin Dieckmann; Georg Widhalm; Karl Rössler; Peter Fischer; Ognian Kalev; Adelheid Wöhrer; Gabor G Kovacs; Ellen Gelpi
Journal:  Brain Pathol       Date:  2022-03-01       Impact factor: 7.611

3.  Clinical Neuropathology image 5-2016: nNeurofibrillary tangle-rich ganglioglioma.

Authors:  Ellen Gelpi; Romana Höftberger; Tanja Würger; Johannes Kerschbaumer; Christian F Freyschlag; Tanja Djurdjevic; Johannes A Hainfellner
Journal:  Clin Neuropathol       Date:  2016 Sep-Oct       Impact factor: 1.368
  3 in total

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