Literature DB >> 7541279

Interaction of clozapine with the histamine H3 receptor in rat brain.

A A Rodrigues1, F P Jansen, R Leurs, H Timmerman, G D Prell.   

Abstract

We examined possible interactions between neuroleptics and the histamine H3 receptor and found an interaction of clozapine with this receptor. In competition binding experiments, using the H3 antagonist, [125I]-iodophenpropit, we observed a Ki of 236 +/- 87 nM. Functionally, clozapine was studied on the H3-mediated inhibition of [3H]-5-hydroxytryptamine ([3H]-5-HT) release from rat brain cortex slices. Clozapine acts as an antagonist with an apparent KB value of 79.5 nM.

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Year:  1995        PMID： 7541279      PMCID： PMC1510403          DOI： 10.1111/j.1476-5381.1995.tb14934.x

Source DB:  PubMed          Journal:  Br J Pharmacol        ISSN： 0007-1188            Impact factor:   8.739


  9 in total

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7.  Decreased histamine H1 receptors in the frontal cortex of brains from patients with chronic schizophrenia.

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8.  Characterization of the binding of the first selective radiolabelled histamine H3-receptor antagonist, [125I]-iodophenpropit, to rat brain.

Authors:  F P Jansen; T S Wu; H P Voss; H W Steinbusch; R C Vollinga; B Rademaker; A Bast; H Timmerman
Journal:  Br J Pharmacol       Date:  1994-10       Impact factor: 8.739

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  9 in total
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Authors:  A Alves-Rodrigues; R Leurs; T S Wu; G D Prell; C Foged; H Timmerman
Journal:  Br J Pharmacol       Date:  1996-08       Impact factor: 8.739

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Authors:  C Y Jin; O Anichtchik; P Panula
Journal:  Br J Pharmacol       Date:  2009-05       Impact factor: 8.739

5.  The Effect of Subchronic Dosing of Ciproxifan and Clobenpropit on Dopamine and Histamine Levels in Rats.

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  6 in total

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