Literature DB >> 7541148

Effect of NGF antibodies on mast cell distribution, histamine and substance P levels in the knee joint of TNF-arthritic transgenic mice.

L Aloe1, L Probert, G Kollias, A Micera, P Tirassa.   

Abstract

We have previously shown an increase in nerve growth factor (NGF) levels and in mast cell (MC) distribution in the synovium of patients affected by rheumatoid arthritis. We now report that purified NGF antibodies injected into arthritic transgenic mice carrying the human tumour necrosis factor-alpha (TNF-alpha) gene caused reduction in the number of MCs, as well as a decrease in histamine and substance P levels within the synovium. These observations suggest that NGF antibody might be useful in studying the role of these pro-inflammatory markers in joint arthritis.

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Year:  1995        PMID： 7541148     DOI： 10.1007/bf00262091

Source DB:  PubMed          Journal:  Rheumatol Int        ISSN： 0172-8172            Impact factor:   2.631


  24 in total

1.  Nerve growth factor and distribution of mast cells in the synovium of adult rats.

Authors:  L Aloe; M A Tuveri; R Levi-Montalcini
Journal:  Clin Exp Rheumatol       Date:  1992 Mar-Apr       Impact factor: 4.473

Review 2.  Arthritis and the nervous system.

Authors:  M Fitzgerald
Journal:  Trends Neurosci       Date:  1989-03       Impact factor: 13.837

Review 3.  The nerve growth factor 35 years later.

Authors:  R Levi-Montalcini
Journal:  Science       Date:  1987-09-04       Impact factor: 47.728

4.  Mediator release from mast cells by nerve growth factor. Neurotrophin specificity and receptor mediation.

Authors:  K Horigome; J C Pryor; E D Bullock; E M Johnson
Journal:  J Biol Chem       Date:  1993-07-15       Impact factor: 5.157

5.  Increased frequency of NGF in sera of rheumatoid arthritis and systemic lupus erythematosus patients.

Authors:  E Dicou; C Masson; W Jabbour; V Nerriere
Journal:  Neuroreport       Date:  1993-12-13       Impact factor: 1.837

6.  Mast cells synthesize, store, and release nerve growth factor.

Authors:  A Leon; A Buriani; R Dal Toso; M Fabris; S Romanello; L Aloe; R Levi-Montalcini
Journal:  Proc Natl Acad Sci U S A       Date:  1994-04-26       Impact factor: 11.205

7.  Increased content and transport of substance P and calcitonin gene-related peptide in sensory nerves innervating inflamed tissue: evidence for a regulatory function of nerve growth factor in vivo.

Authors:  J Donnerer; R Schuligoi; C Stein
Journal:  Neuroscience       Date:  1992-08       Impact factor: 3.590

8.  Lipopolysaccharide induces substance P in sympathetic ganglia via ganglionic interleukin-1 production.

Authors:  A M Shadiack; C D Carlson; M Ding; R P Hart; G M Jonakait
Journal:  J Neuroimmunol       Date:  1994-01       Impact factor: 3.478

9.  Studies on carrageenan-induced arthritis in adult rats: presence of nerve growth factor and role of sympathetic innervation.

Authors:  L Aloe; M A Tuveri; R Levi-Montalcini
Journal:  Rheumatol Int       Date:  1992       Impact factor: 2.631

10.  Transgenic mice expressing human tumour necrosis factor: a predictive genetic model of arthritis.

Authors:  J Keffer; L Probert; H Cazlaris; S Georgopoulos; E Kaslaris; D Kioussis; G Kollias
Journal:  EMBO J       Date:  1991-12       Impact factor: 11.598
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  5 in total

1.  Blockage of nerve growth factor modulates T cell responses and inhibits allergic inflammation in a mouse model of asthma.

Authors:  Yan Shi; Yingli Jin; Weiying Guo; Libo Chen; Chaoying Liu; Xiaohong Lv
Journal:  Inflamm Res       Date:  2012-08-08       Impact factor: 4.575

2.  Cholecystokinin-8 enhances nerve growth factor synthesis and promotes recovery of capsaicin-induced sensory deficit.

Authors:  L Manni; T Lundeberg; P Tirassa; L Aloe
Journal:  Br J Pharmacol       Date:  2000-02       Impact factor: 8.739

3.  Nerve growth factor-beta induces mast-cell marker expression during in vitro culture of human umbilical cord blood cells.

Authors:  P Welker; J Grabbe; B Gibbs; T Zuberbier; B M Henz
Journal:  Immunology       Date:  2000-03       Impact factor: 7.397

4.  Nerve growth factor and its high-affinity receptor in chronic pancreatitis.

Authors:  H Friess; Z W Zhu; F F di Mola; C Kulli; H U Graber; A Andren-Sandberg; A Zimmermann; M Korc; M Reinshagen; M W Büchler
Journal:  Ann Surg       Date:  1999-11       Impact factor: 12.969

Review 5.  Nerve growth factor: a neurokine orchestrating neuroimmune-endocrine functions.

Authors:  S D Skaper
Journal:  Mol Neurobiol       Date:  2001 Aug-Dec       Impact factor: 5.590
  5 in total

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