OBJECTIVE: Extraarticular rheumatoid arthritis (RA) is almost unknown in Marseille in southern France. We investigated whether this was due to rare expression of the HLA-DRB1 shared epitope. METHODS: HLA-DRB1 alleles were characterized in 73 patients with RA and 108 controls by polymerase chain reaction amplification and oligonucleotide hybridization. RESULTS: In patients with RA, 76% expressed the shared epitope (46% DR1, 45% DR4). Four HLA-DRB1 alleles were positively associated with disease: DRB1*0101, DRB1*0401, DRB1*0404, DRB1*0405. Patients with double dose shared epitope had the most severe articular damage, but no extraarticular disease. CONCLUSION: In Marseille, 76% of patients with RA are shared epitope positive. Still, most do not develop extraarticular RA. This may be caused by the low frequency of HLA-DRB1*0401 in this population.
OBJECTIVE:Extraarticular rheumatoid arthritis (RA) is almost unknown in Marseille in southern France. We investigated whether this was due to rare expression of the HLA-DRB1 shared epitope. METHODS:HLA-DRB1 alleles were characterized in 73 patients with RA and 108 controls by polymerase chain reaction amplification and oligonucleotide hybridization. RESULTS: In patients with RA, 76% expressed the shared epitope (46% DR1, 45% DR4). Four HLA-DRB1 alleles were positively associated with disease: DRB1*0101, DRB1*0401, DRB1*0404, DRB1*0405. Patients with double dose shared epitope had the most severe articular damage, but no extraarticular disease. CONCLUSION: In Marseille, 76% of patients with RA are shared epitope positive. Still, most do not develop extraarticular RA. This may be caused by the low frequency of HLA-DRB1*0401 in this population.
Authors: T N Hyphantis; M Bai; V Siafaka; A N Georgiadis; P V Voulgari; V Mavreas; A A Drosos Journal: Rheumatol Int Date: 2005-12-09 Impact factor: 2.631
Authors: Doua F Azzouz; Justyna M Rak; Nathalie Balandraud; Isabelle Auger; Marielle Martin; Jean Roudier; Nathalie C Lambert Journal: Chimerism Date: 2010 Jul-Sep