Literature DB >> 7540267

Lesions to terminals of noradrenergic locus coeruleus neurones do not inhibit opiate withdrawal behaviour in rats.

B Chieng1, M J Christie.   

Abstract

The involvement of neurones of the locus coeruleus (LC) in expression of opiate withdrawal behaviour was tested in morphine-dependent rats using N-2-chloroethyl-N-ethyl-2-bromobenzylamine (DSP4), a neurotoxin selective for noradrenergic terminals arising from LC. Lesions were validated by determination of cortical noradrenaline concentrations using gas chromatography-mass spectrometry, inhibition of the post-decapitation hindpaw reflex and dopamine-beta-hydroxylase immunohistochemistry. Lesions did not inhibit the expression of any naloxone-precipitated withdrawal signs. These results suggest no involvement of noradrenergic LC neurones in expression of the overt signs of opiate withdrawal, and raise the possibility that previous microinjection and electrolytic lesion studies were confounded by effects on nearby brain regions.

Entities:  

Mesh：

Substances：

Year:  1995        PMID： 7540267     DOI： 10.1016/0304-3940(95)11276-3

Source DB:  PubMed          Journal:  Neurosci Lett        ISSN： 0304-3940            Impact factor:   3.046


  15 in total

1.  Neuroadaptation of GABAergic transmission in the central amygdala during chronic morphine treatment.

Authors:  Michal Bajo; Marisa Roberto; Samuel G Madamba; George Robert Siggins
Journal:  Addict Biol       Date:  2010-12-23       Impact factor: 4.280

2.  Increased opioid inhibition of GABA release in nucleus accumbens during morphine withdrawal.

Authors:  B Chieng; J T Williams
Journal:  J Neurosci       Date:  1998-09-01       Impact factor: 6.167

3.  Restricted role of CRF1 receptor for the activity of brainstem catecholaminergic neurons in the negative state of morphine withdrawal.

Authors:  Juan-Antonio Garcia-Carmona; Pilar Almela; Alberto Baroja-Mazo; M Victoria Milanes; M Luisa Laorden
Journal:  Psychopharmacology (Berl)       Date:  2011-09-21       Impact factor: 4.530

4.  Decreases in endogenous opioid peptides in the rat medullo-coerulear pathway after chronic morphine treatment.

Authors:  E J Van Bockstaele; J Peoples; A S Menko; K McHugh; G Drolet
Journal:  J Neurosci       Date:  2000-12-01       Impact factor: 6.167

5.  Local opioid withdrawal in rat single periaqueductal gray neurons in vitro.

Authors:  B Chieng; M D Christie
Journal:  J Neurosci       Date:  1996-11-15       Impact factor: 6.167

6.  Activation of coeruleospinal noradrenergic inhibitory controls during withdrawal from morphine in the rat.

Authors:  D S Rohde; A I Basbaum
Journal:  J Neurosci       Date:  1998-06-01       Impact factor: 6.167

Review 7.  Neuroadaptive responses in brainstem noradrenergic nuclei following chronic morphine exposure.

Authors:  E J Van Bockstaele; A S Menko; G Drolet
Journal:  Mol Neurobiol       Date:  2001 Apr-Jun       Impact factor: 5.590

8.  Pre- and postsynaptic regulation of locus coeruleus neurons after chronic morphine treatment: a study of GIRK-knockout mice.

Authors:  Maria Torrecilla; Nidia Quillinan; John T Williams; Kevin Wickman
Journal:  Eur J Neurosci       Date:  2008-08       Impact factor: 3.386

9.  Absence and rescue of morphine withdrawal in GIRK/Kir3 knock-out mice.

Authors:  Hans G Cruz; Frédérique Berton; Monica Sollini; Christophe Blanchet; Marco Pravetoni; Kevin Wickman; Christian Lüscher
Journal:  J Neurosci       Date:  2008-04-09       Impact factor: 6.167

10.  Involvement of noradrenergic system within the central nucleus of the amygdala in naloxone-precipitated morphine withdrawal-induced conditioned place aversion in rats.

Authors:  Takeshi Watanabe; Takayuki Nakagawa; Rie Yamamoto; Akifumi Maeda; Masabumi Minami; Masamichi Satoh
Journal:  Psychopharmacology (Berl)       Date:  2003-05-27       Impact factor: 4.530
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.