Literature DB >> 7539249

Transforming growth factor beta 1 inhibits IL-3- and IL-4-dependent mouse connective tissue-type mast cell proliferation.

N Toyota1, Y Hashimoto, S Matsuo, H Iizuka.   

Abstract

Transforming growth factor beta 1 (TGF beta 1) is a regulator of cell proliferation and differentiation. Using a mouse peritoneal cell-derived mast cell culture system, we investigated the effects of TGF beta 1 on mast cell proliferation. TGF beta 1 inhibited IL-3- and IL-4-dependent connective tissue-type mast cell proliferation. The effect was concentration dependent: 50% inhibition was observed with 1.0 ng/ml TGF beta 1 and the maximal inhibitory effect (no proliferation), was observed with 10 ng/ml. Flow cytometric analysis suggested that the inhibitory effect of TGF beta 1 was due to blocking of both G1 and G2 phases. Both control and TGF beta 1-treated mast cells showed similar histamine release induced by the calcium ionophore, A23187. TGF beta 1 seems to be an important negative regulator of connective tissue-type mast cell proliferation with apparently no appreciable effect on mast cell function.

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Year:  1995        PMID： 7539249     DOI： 10.1007/bf01262332

Source DB:  PubMed          Journal:  Arch Dermatol Res        ISSN： 0340-3696            Impact factor:   3.017


  32 in total

Review 1.  Regulation of epithelial cell proliferation by transforming growth factors.

Authors:  C C Bascom; N J Sipes; R J Coffey; H L Moses
Journal:  J Cell Biochem       Date:  1989-01       Impact factor: 4.429

2.  Administration of 8-methoxypsoralen and ultraviolet A irradiation (PUVA) induces turnover of mast cells in the skin of C57BL/6 mice.

Authors:  N Toyota; Y Kitamura; K Ogawa
Journal:  J Invest Dermatol       Date:  1990-09       Impact factor: 8.551

3.  TGF-beta 1 inhibition of c-myc transcription and growth in keratinocytes is abrogated by viral transforming proteins with pRB binding domains.

Authors:  J A Pietenpol; R W Stein; E Moran; P Yaciuk; R Schlegel; R M Lyons; M R Pittelkow; K Münger; P M Howley; H L Moses
Journal:  Cell       Date:  1990-06-01       Impact factor: 41.582

Review 4.  Mast cell heterogeneity: derivation and function, with emphasis on the intestine.

Authors:  J Bienenstock; A D Befus; F Pearce; J Denburg; R Goodacre
Journal:  J Allergy Clin Immunol       Date:  1982-12       Impact factor: 10.793

5.  Association of human papillomavirus types 16 and 18 E6 proteins with p53.

Authors:  B A Werness; A J Levine; P M Howley
Journal:  Science       Date:  1990-04-06       Impact factor: 47.728

6.  Transforming growth factor beta 1 suppression of c-myc gene transcription: role in inhibition of keratinocyte proliferation.

Authors:  J A Pietenpol; J T Holt; R W Stein; H L Moses
Journal:  Proc Natl Acad Sci U S A       Date:  1990-05       Impact factor: 11.205

7.  Identification in culture of a class of hemopoietic colony-forming units with extensive capability to self-renew and generate multipotential hemopoietic colonies.

Authors:  T Nakahata; M Ogawa
Journal:  Proc Natl Acad Sci U S A       Date:  1982-06       Impact factor: 11.205

8.  Characterization of a membrane receptor for transforming growth factor-beta in normal rat kidney fibroblasts.

Authors:  C A Frolik; L M Wakefield; D M Smith; M B Sporn
Journal:  J Biol Chem       Date:  1984-09-10       Impact factor: 5.157

9.  New class of transforming growth factors potentiated by epidermal growth factor: isolation from non-neoplastic tissues.

Authors:  A B Roberts; M A Anzano; L C Lamb; J M Smith; M B Sporn
Journal:  Proc Natl Acad Sci U S A       Date:  1981-09       Impact factor: 11.205

Review 10.  Multiple type-beta transforming growth factors and their receptors.

Authors:  J Massagué; S Cheifetz; R A Ignotz; F T Boyd
Journal:  J Cell Physiol Suppl       Date:  1987
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  9 in total

1.  Inhibitory effect of 1 alpha,25-dihydroxyvitamin D3 on mast cell proliferation and A23187-induced histamine release, also accompanied by a decreased c-kit receptor.

Authors:  N Toyota; H Sakai; H Takahashi; Y Hashimoto; H Iizuka
Journal:  Arch Dermatol Res       Date:  1996-10       Impact factor: 3.017

2.  ADAM10 is required for SCF-induced mast cell migration.

Authors:  Travis W Faber; Nicholas A Pullen; Josephine F A Fernando; Elizabeth Motunrayo Kolawole; Jamie J A McLeod; Marcela Taruselli; Kathryn L Williams; Kevin O Rivera; Brian O Barnstein; Daniel H Conrad; John J Ryan
Journal:  Cell Immunol       Date:  2014-05-21       Impact factor: 4.868

Review 3.  Mast cells as sources of cytokines, chemokines, and growth factors.

Authors:  Kaori Mukai; Mindy Tsai; Hirohisa Saito; Stephen J Galli
Journal:  Immunol Rev       Date:  2018-03       Impact factor: 12.988

4.  Growth, phenotype, and function of human intestinal mast cells are tightly regulated by transforming growth factor beta1.

Authors:  T Gebhardt; A Lorentz; F Detmer; C Trautwein; H Bektas; M P Manns; S C Bischoff
Journal:  Gut       Date:  2005-07       Impact factor: 23.059

5.  TGF-beta 1 inhibits mast cell Fc epsilon RI expression.

Authors:  Gregorio Gomez; Carlos D Ramirez; Juan Rivera; Manish Patel; Farnaz Norozian; Harry V Wright; Mohit V Kashyap; Brian O Barnstein; Krista Fischer-Stenger; Lawrence B Schwartz; Christopher L Kepley; John J Ryan
Journal:  J Immunol       Date:  2005-05-15       Impact factor: 5.422

6.  TGF-beta1 attenuates mediator release and de novo Kit expression by human skin mast cells through a Smad-dependent pathway.

Authors:  Wei Zhao; Gregorio Gomez; Shao-Hua Yu; John J Ryan; Lawrence B Schwartz
Journal:  J Immunol       Date:  2008-11-15       Impact factor: 5.422

7.  Genotype-dependent effects of TGF-β1 on mast cell function: targeting the Stat5 pathway.

Authors:  Josephine Fernando; Travis W Faber; Nicholas A Pullen; Yves T Falanga; Elizabeth Motunrayo Kolawole; Carole A Oskeritzian; Brian O Barnstein; Geethani Bandara; Geqiang Li; Lawrence B Schwartz; Sarah Spiegel; David B Straus; Daniel H Conrad; Kevin D Bunting; John J Ryan
Journal:  J Immunol       Date:  2013-09-25       Impact factor: 5.422

8.  The Fyn-STAT5 Pathway: A New Frontier in IgE- and IgG-Mediated Mast Cell Signaling.

Authors:  Nicholas A Pullen; Yves T Falanga; Johanna K Morales; John J Ryan
Journal:  Front Immunol       Date:  2012-05-11       Impact factor: 7.561

9.  miR-122-SOCS1-JAK2 axis regulates allergic inflammation and allergic inflammation-promoted cellular interactions.

Authors:  Kyeonga Noh; Misun Kim; Youngmi Kim; Hanearl Kim; Hyuna Kim; Jaehwan Byun; Yeongseo Park; Hansoo Lee; Yun Sil Lee; Jongseon Choe; Young Myeong Kim; Dooil Jeoung
Journal:  Oncotarget       Date:  2017-07-10
  9 in total

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