Literature DB >> 7539025

Recombinant soluble CD14 prevents mortality in mice treated with endotoxin (lipopolysaccharide).

A Haziot1, G W Rong, X Y Lin, J Silver, S M Goyert.   

Abstract

Endotoxic shock is a life-threatening condition mediated by cytokines released after exposure to bacterial LPS/endotoxin. Activation of monocytes and neutrophils by the binding of LPS to the membrane receptor, CD14, plays a key role in this response. Furthermore, a soluble form of the CD14 receptor enhances the endothelial cell response to LPS. We show here that despite the agonist effects of soluble CD14 on the endothelial cell response to LPS, recombinant soluble CD14 is able to protect mice from LPS-induced lethality. This protection appears to be associated with the inhibition of TNF-alpha release. These results suggest that the soluble CD14 receptor may represent a new form of therapy for endotoxic shock in humans.

Entities:  

Mesh：

Substances：

Year:  1995        PMID： 7539025

Source DB:  PubMed          Journal:  J Immunol        ISSN： 0022-1767            Impact factor:   5.422


  30 in total

Review 1.  [Endotoxins. Pathogenetic meaning of sepsis].

Authors:  H Rensing
Journal:  Anaesthesist       Date:  2003-12       Impact factor: 1.041

Review 2.  The inflammatory cytokines. New developments in the pathophysiology and treatment of septic shock.

Authors:  M P Glauser
Journal:  Drugs       Date:  1996       Impact factor: 9.546

3.  Serum factors, cell membrane CD14, and beta2 integrins are not required for activation of bovine macrophages by lipopolysaccharide.

Authors:  T W Jungi; H Sager; H Adler; M Brcic; H Pfister
Journal:  Infect Immun       Date:  1997-09       Impact factor: 3.441

4.  Changes in endotoxin-binding proteins during major elective surgery: important role for soluble CD14 in regulation of biological activity of systemic endotoxin.

Authors:  N Hiki; D Berger; M A Dentener; Y Mimura; W A Buurman; C Prigl; M Seidelmann; E Tsuji; M Kaminishi; H G Beger
Journal:  Clin Diagn Lab Immunol       Date:  1999-11

5.  LPS-binding protein protects mice from septic shock caused by LPS or gram-negative bacteria.

Authors:  N Lamping; R Dettmer; N W Schröder; D Pfeil; W Hallatschek; R Burger; R R Schumann
Journal:  J Clin Invest       Date:  1998-05-15       Impact factor: 14.808

6.  Endotoxin binding and elimination by monocytes: secretion of soluble CD14 represents an inducible mechanism counteracting reduced expression of membrane CD14 in patients with sepsis and in a patient with paroxysmal nocturnal hemoglobinuria.

Authors:  N Hiki; D Berger; C Prigl; E Boelke; H Wiedeck; M Seidelmann; L Staib; M Kaminishi; T Oohara; H G Beger
Journal:  Infect Immun       Date:  1998-03       Impact factor: 3.441

Review 7.  Novel pharmacologic approaches to the management of sepsis: targeting the host inflammatory response.

Authors:  Derek S Wheeler; Basilia Zingarelli; William J Wheeler; Hector R Wong
Journal:  Recent Pat Inflamm Allergy Drug Discov       Date:  2009-06

Review 8.  Receptors, mediators, and mechanisms involved in bacterial sepsis and septic shock.

Authors:  Edwin S Van Amersfoort; Theo J C Van Berkel; Johan Kuiper
Journal:  Clin Microbiol Rev       Date:  2003-07       Impact factor: 26.132

Review 9.  Advances in sepsis therapy.

Authors:  Thomas Glück; Steven M Opal
Journal:  Drugs       Date:  2004       Impact factor: 9.546

10.  Pathogenic roles of CD14, galectin-3, and OX40 during experimental cerebral malaria in mice.

Authors:  Miranda S Oakley; Victoria Majam; Babita Mahajan; Noel Gerald; Vivek Anantharaman; Jerrold M Ward; Lawrence J Faucette; Thomas F McCutchan; Hong Zheng; Masaki Terabe; Jay A Berzofsky; L Aravind; Sanjai Kumar
Journal:  PLoS One       Date:  2009-08-27       Impact factor: 3.240
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.