Literature DB >> 7538962

FKBP39, a Drosophila member of a family of proteins that bind the immunosuppressive drug FK506.

U Theopold1, L Dal Zotto, D Hultmark.   

Abstract

A cDNA, coding for the first Drosophila melanogaster homolog of a family of proteins (FK506-binding proteins, FKBPs) which bind to the immunosuppressive drug FK506, was isolated. The deduced aa sequence corresponds to a 39-kDa product (FKBP39) which, besides a domain with similarity to FKBPs, has a highly charged domain with two strongly acidic stretches. The transcript could be detected in all developmental stages, with the highest expression in the embryo. In adult flies, the strongest signal was detected in the ovaries. Although the FKBP39 gene is expressed in the immunocompetent D. melanogaster blood cell line, mbn-2, the antibacterial defense reaction of these cells is unaffected by FK506.

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Year:  1995        PMID： 7538962     DOI： 10.1016/0378-1119(95)00019-3

Source DB:  PubMed          Journal:  Gene        ISSN： 0378-1119            Impact factor:   3.688


  10 in total

1.  Nucleolar protein B23 has molecular chaperone activities.

Authors:  A Szebeni; M O Olson
Journal:  Protein Sci       Date:  1999-04       Impact factor: 6.725

2.  Novel structure of a high molecular weight FK506 binding protein from Arabidopsis thaliana.

Authors:  V A Vucich; C S Gasser
Journal:  Mol Gen Genet       Date:  1996-10-16

3.  Gene expression profiling identifies FKBP39 as an inhibitor of autophagy in larval Drosophila fat body.

Authors:  G Juhász; L G Puskás; O Komonyi; B Erdi; P Maróy; T P Neufeld; M Sass
Journal:  Cell Death Differ       Date:  2007-03-16       Impact factor: 15.828

4.  FKBP39 Controls the Larval Stage JH Activity and Development in Drosophila melanogaster.

Authors:  Xinyu Wang; Ying Zhou; Jianwen Guan; Yang Cheng; Yingying Lu; Youheng Wei
Journal:  Insects       Date:  2022-03-28       Impact factor: 3.139

5.  Nucleoplasmin-like domain of FKBP39 from Drosophila melanogaster forms a tetramer with partly disordered tentacle-like C-terminal segments.

Authors:  Małgorzata Kozłowska; Aneta Tarczewska; Michał Jakób; Dominika Bystranowska; Michał Taube; Maciej Kozak; Mariusz Czarnocki-Cieciura; Andrzej Dziembowski; Marek Orłowski; Katarzyna Tkocz; Andrzej Ożyhar
Journal:  Sci Rep       Date:  2017-01-11       Impact factor: 4.379

6.  A genome-wide survey for host response of silkworm, Bombyx mori during pathogen Bacillus bombyseptieus infection.

Authors:  Lulin Huang; Tingcai Cheng; Pingzhen Xu; Daojun Cheng; Ting Fang; Qingyou Xia
Journal:  PLoS One       Date:  2009-12-01       Impact factor: 3.240

7.  FKBP39 controls nutrient dependent Nprl3 expression and TORC1 activity in Drosophila.

Authors:  Ying Zhou; Jian Guo; Xinyu Wang; Yang Cheng; Jianwen Guan; Priyam Barman; Ming-An Sun; Yuanyuan Fu; Wanhong Wei; Congjing Feng; Mary A Lilly; Youheng Wei
Journal:  Cell Death Dis       Date:  2021-06-02       Impact factor: 8.469

8.  Catalogue of epidermal genes: genes expressed in the epidermis during larval molt of the silkworm Bombyx mori.

Authors:  Shun Okamoto; Ryo Futahashi; Tetsuya Kojima; Kazuei Mita; Haruhiko Fujiwara
Journal:  BMC Genomics       Date:  2008-08-22       Impact factor: 3.969

9.  Identification and comparative analysis of the peptidyl-prolyl cis/trans isomerase repertoires of H. sapiens, D. melanogaster, C. elegans, S. cerevisiae and Sz. pombe.

Authors:  Trevor J Pemberton; John E Kay
Journal:  Comp Funct Genomics       Date:  2005

Review 10.  Comparative analysis of FKBP family protein: evaluation, structure, and function in mammals and Drosophila melanogaster.

Authors:  George Ghartey-Kwansah; Zhongguang Li; Rui Feng; Liyang Wang; Xin Zhou; Frederic Z Chen; Meng Meng Xu; Odell Jones; Yulian Mu; Shawn Chen; Joseph Bryant; Williams B Isaacs; Jianjie Ma; Xuehong Xu
Journal:  BMC Dev Biol       Date:  2018-03-27       Impact factor: 1.978
  10 in total

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