| Literature DB >> 7538896 |
R E Richmond1, J H Carter, H W Carter, F B Daniel, A B DeAngelo.
Abstract
We examined the incidence of proliferative lesions, hyperplastic nodules and altered hepatic foci, in male F344 rat liver, to determine their preneoplastic potential during dichloroacetic acid (DCA)-induced hepatocarcinogenesis. Immunohistochemical and image analysis methods were used to detect the expression of 6 histochemical markers of neoplastic cells; p21 ras, p39 c-jun, p55 c-fos, aldehyde dehydrogenase (ALDH), glutathione s-transferase (GST-p), and alpha fetoprotein (AFP) during DCA-induced hepatocarcinogenesis. Our results were consistent with our previous data and suggested that the hyperplastic nodules, rather than altered hepatic foci, is a putative preneoplastic lesion during DCA-induced hepatocarcinogenesis in the male F344 rat.Entities:
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Year: 1995 PMID： 7538896 DOI： 10.1016/0304-3835(94)03756-9
Source DB: PubMed Journal: Cancer Lett ISSN： 0304-3835 Impact factor: 8.679