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Literature DB >> 7538447

Alteration of expression in integrin beta 1-subunit correlates with invasion and metastasis in colorectal cancer.

S Fujita¹, M Watanabe, T Kubota, T Teramoto, M Kitajima.

Abstract

We have investigated the expression of the integrin beta 1 subunit in 51 colorectal cancer tissues using immunoblotting and have determined the relationship between expression and clinical stage. In comparison with normal mucosa the pre-beta-subunit (the precursor of beta 1-subunit) was increased in 15 cases and decreased in two cases, and expression of the beta 1-subunit was decreased in two cases. These alterations of expression of the beta 1-subunit were significantly correlated with lymph node metastasis and depth of invasion (P < 0.01). These results suggest that integrin plays an important role in the invasion and metastasis of colorectal cancer.

Entities: Disease

Mesh：

Substances：
Integrin beta1
Integrins

Year: 1995 PMID： 7538447 DOI： 10.1016/0304-3835(95)03735-f

Source DB: PubMed Journal: Cancer Lett ISSN： 0304-3835 Impact factor: 8.679

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Cited

17 in total

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Alteration of expression in integrin beta 1-subunit correlates with invasion and metastasis in colorectal cancer.

1. Chemokines induce the cellular migration of MCF-7 human breast carcinoma cells: subpopulations of tumour cells display positive and negative chemotaxis and differential in vivo growth potentials.

2. Integrin expression levels correlate with invasion, metastasis and prognosis of oral squamous cell carcinoma.

Review 3. Tissue architecture: the ultimate regulator of epithelial function?

4. Beta1 integrin inhibitory antibody induces apoptosis of breast cancer cells, inhibits growth, and distinguishes malignant from normal phenotype in three dimensional cultures and in vivo.

5. Adenoviruses with an αvβ integrin targeting moiety in the fiber shaft or the HI-loop increase tumor specificity without compromising antitumor efficacy in magnetic resonance imaging of colorectal cancer metastases.

6. Prognostic value of β1 integrin expression in colorectal liver metastases.

7. NF-κB regulates radioresistance mediated by β1-integrin in three-dimensional culture of breast cancer cells.

Review 8. Cell surface markers in colorectal cancer prognosis.

Review 9. Molecular identification and targeting of colorectal cancer stem cells.

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