| Literature DB >> 7538442 |
G J Freeman1, V A Boussiotis, A Anumanthan, G M Bernstein, X Y Ke, P D Rennert, G S Gray, J G Gribben, L M Nadler.
Abstract
The functional necessity for two CD28 counterreceptors (B7-1 and B7-2) is presently unknown. B7-1 and B7-2 equivalently costimulate IL-2 and interferon-gamma (IFN gamma) production and IL-2 receptor alpha and gamma chain expression. B7-2 induces significantly more IL-4 production than B7-1, with the greatest difference seen in naive T cells. Repetitive costimulation of CD4+ CD45RA+ T cells with B7-2 results in moderate levels of both IL-4 and IL-2, whereas repetitive costimulation with B7-1 results in high levels of IL-2 and low levels of IL-4. Therefore, B7-1 and B7-2 costimulation mediate distinct outcomes, since B7-2 provides an initial signal to induce naive T cells to become IL-4 producers, thereby directing the immune response more towards Th0/Th2, whereas B7-1 is a more neutral differentiative signal.Entities:
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Year: 1995 PMID： 7538442 DOI： 10.1016/1074-7613(95)90032-2
Source DB: PubMed Journal: Immunity ISSN： 1074-7613 Impact factor: 31.745