Literature DB >> 7538352

Ex vivo expansion of cord blood-derived stem cells and progenitors.

M A Moore1, I Hoskins.   

Abstract

Cord blood-derived CD34+ cells have proved superior to adult marrow or elicited peripheral blood in ex vivo cell and progenitor expansion. In addition, cord blood-derived cells with a phenotype and function of early stem cells (e.g., long-term culture-initiating cells) can be expanded in vitro in the presence of a combination of cytokines by 15- to 20-fold over 7-14 days. These observations suggest that ex vivo expansion of cord blood CD34+ cells will permit improved engraftment of adults and will prove effective in retroviral-mediated gene transfection of early stem cell populations.

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Year:  1994        PMID： 7538352

Source DB:  PubMed          Journal:  Blood Cells        ISSN： 0340-4684


  11 in total

1.  Umbilical cord blood: an expandable resource.

Authors:  M A Moore
Journal:  J Clin Invest       Date:  2000-04       Impact factor: 14.808

2.  Chemotaxis of primitive hematopoietic cells in response to stromal cell-derived factor-1.

Authors:  D Y Jo; S Rafii; T Hamada; M A Moore
Journal:  J Clin Invest       Date:  2000-01       Impact factor: 14.808

3.  Cytokine modulation of murine stem cell engraftment: the role of adherence to plastic surfaces.

Authors:  Stefan O Peters; Houri K Habibian; Peter J Quesenberry
Journal:  Int J Hematol       Date:  2002-07       Impact factor: 2.490

4.  Scalable Manufacturing of Human Hematopoietic Stem/Progenitor Cells Exploiting a Co-culture Platform with Mesenchymal Stromal Cells.

Authors:  Ana Fernandes-Platzgummer; Pedro Z Andrade; Joaquim M S Cabral; Cláudia Lobato da Silva
Journal:  Methods Mol Biol       Date:  2021

5.  Noninvasive bioluminescent imaging demonstrates long-term multilineage engraftment of ex vivo-expanded CD34-selected umbilical cord blood cells.

Authors:  David Steiner; Juri Gelovani; Barbara Savoldo; Simon N Robinson; William K Decker; Nathalie Brouard; Amer Najjar; Dongxia Xing; Hong Yang; Sufang Li; Frank Marini; Patrick A Zweidler-McKay; Catherine M Bollard; Elizabeth J Shpall; Gianpietro Dotti; Paul J Simmons
Journal:  Stem Cells       Date:  2009-08       Impact factor: 6.277

6.  Human chemokines: enhancement of specific activity and effects in vitro on normal and leukemic progenitors and a factor-dependent cell line and in vivo in mice.

Authors:  H E Broxmeyer; S Cooper; N Hague; L Benninger; A Sarris; K Cornetta; S Vadhan-Raj; P Hendrie; C Mantel
Journal:  Ann Hematol       Date:  1995-11       Impact factor: 3.673

7.  Differential cytokine effects on primitive (CD34+CD38-) human hematopoietic cells: novel responses to Flt3-ligand and thrombopoietin.

Authors:  A L Petzer; P W Zandstra; J M Piret; C J Eaves
Journal:  J Exp Med       Date:  1996-06-01       Impact factor: 14.307

8.  The Culture-Repopulating Ability assays and incubation in low oxygen: a simple way to test drugs on leukaemia stem or progenitor cells.

Authors:  Maria Grazia Cipolleschi; Elisabetta Rovida; Persio Dello Sbarba
Journal:  Curr Pharm Des       Date:  2013       Impact factor: 3.116

9.  Ex Vivo Expansion of Hematopoietic Stem and Progenitor Cells from Umbilical Cord Blood.

Authors:  E V Sotnezova; E R Andreeva; A I Grigoriev; L B Buravkova
Journal:  Acta Naturae       Date:  2016 Jul-Sep       Impact factor: 1.845

10.  Application of proteoglycan extracted from the nasal cartilage of salmon heads for ex vivo expansion of hematopoietic progenitor cells derived from human umbilical cord blood.

Authors:  Ikuo Kashiwakura; Kenji Takahashi; Keiichi Takagaki
Journal:  Glycoconj J       Date:  2007-03-28       Impact factor: 3.009
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