Literature DB >> 7537841

Transmission of hepatitis C virus to children and husbands by women infected with contaminated anti-D immunoglobulin.

H Meisel1, A Reip, B Faltus, M Lu, H Porst, M Wiese, M Roggendorf, D H Krüger.   

Abstract

In 1978-79 a single-source outbreak of hepatitis C occurred in 2533 women who had received virus-contaminated anti-D immunoglobulin. Children and husbands of 74 women with self-limited, and of 86 women with chronic, hepatitis C were followed up for over 10-15 years. In 3 of 231 investigated children (1.3%) serological evidence for HCV infection was found. However, none of the children developed an apparent or chronic hepatitis. Serum samples of the 94 husbands investigated showed no HCV antibodies or HCV RNA. We consider the risk of intrauterine or perinatal transmission of HCV, as well as that of transmission through close family contacts, to be low. No evidence was found for sexual transmission for women to men.

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Year:  1995        PMID： 7537841     DOI： 10.1016/s0140-6736(95)91992-9

Source DB:  PubMed          Journal:  Lancet        ISSN： 0140-6736            Impact factor:   79.321


  17 in total

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