Literature DB >> 7537157

Regulation of the interferon-induced PKR: can viruses cope?

M G Katze1.   

Abstract

Viruses that fail to block the lethal effects of the double-stranded-RNA-activated protein kinase (PKR) may be doomed; why do so many viruses go to so much trouble to downregulate this interferon-induced protein kinase? PKR may regulate cell growth and proliferation in uninfected cells, suggesting that it also participates in the antiproliferative arm of the interferon response.

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Year:  1995        PMID： 7537157     DOI： 10.1016/s0966-842x(00)88880-0

Source DB:  PubMed          Journal:  Trends Microbiol        ISSN： 0966-842X            Impact factor:   17.079


  64 in total

1.  The C-terminal, third conserved motif of the protein activator PACT plays an essential role in the activation of double-stranded-RNA-dependent protein kinase (PKR).

Authors:  Xu Huang; Brian Hutchins; Rekha C Patel
Journal:  Biochem J       Date:  2002-08-15       Impact factor: 3.857

2.  The herpes simplex virus type 1 U(S)11 protein interacts with protein kinase R in infected cells and requires a 30-amino-acid sequence adjacent to a kinase substrate domain.

Authors:  Kevin A Cassady; Martin Gross
Journal:  J Virol       Date:  2002-03       Impact factor: 5.103

Review 3.  Post-transcriptional gene silencing mutants.

Authors:  J B Morel; H Vaucheret
Journal:  Plant Mol Biol       Date:  2000-06       Impact factor: 4.076

4.  The protein kinase PKR: a molecular clock that sequentially activates survival and death programs.

Authors:  Olivier Donzé; Jing Deng; Joseph Curran; Robert Sladek; Didier Picard; Nahum Sonenberg
Journal:  EMBO J       Date:  2004-01-29       Impact factor: 11.598

5.  The Hsp90 chaperone complex is both a facilitator and a repressor of the dsRNA-dependent kinase PKR.

Authors:  O Donzé; T Abbas-Terki; D Picard
Journal:  EMBO J       Date:  2001-07-16       Impact factor: 11.598

6.  Double-stranded RNA is produced by positive-strand RNA viruses and DNA viruses but not in detectable amounts by negative-strand RNA viruses.

Authors:  Friedemann Weber; Valentina Wagner; Simon B Rasmussen; Rune Hartmann; Søren R Paludan
Journal:  J Virol       Date:  2006-05       Impact factor: 5.103

7.  Expression of PACT is regulated by Sp1 transcription factor.

Authors:  Stephen Fasciano; Amanda Kaufman; Rekha C Patel
Journal:  Gene       Date:  2006-10-17       Impact factor: 3.688

Review 8.  Regulatory mechanisms of viral hepatitis B and C.

Authors:  G Waris; A Siddiqui
Journal:  J Biosci       Date:  2003-04       Impact factor: 1.826

9.  Inhibition of protein kinase R activation and upregulation of GADD34 expression play a synergistic role in facilitating coronavirus replication by maintaining de novo protein synthesis in virus-infected cells.

Authors:  Xiaoxing Wang; Ying Liao; Pei Ling Yap; Kim J Png; James P Tam; Ding Xiang Liu
Journal:  J Virol       Date:  2009-09-23       Impact factor: 5.103

10.  XBP-1 regulates a subset of endoplasmic reticulum resident chaperone genes in the unfolded protein response.

Authors:  Ann-Hwee Lee; Neal N Iwakoshi; Laurie H Glimcher
Journal:  Mol Cell Biol       Date:  2003-11       Impact factor: 4.272
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