| Literature DB >> 7535875 |
P Atkison1, G Joubert, A Barron, D Grant, K Paradis, E Seidman, W Wall, H Rosenberg, J Howard, S Williams.
Abstract
Reported side-effects of tacrolimus, a potent immunosuppressive agent, have not included cardiotoxicity. We describe 5 consecutive paediatric transplant recipients (3 small bowel with or without liver and 2 liver) who received tacrolimus. 2 developed congestive heart failure and hypertrophic obstructive cardiomyopathy which resolved after changing to cyclosporin. In the other 3 patients the cardiomyopathy regressed or improved with a lower dose of tacrolimus or after stopping the drug.Entities:
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Year: 1995 PMID： 7535875 DOI： 10.1016/s0140-6736(95)90011-x
Source DB: PubMed Journal: Lancet ISSN： 0140-6736 Impact factor: 79.321