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Literature DB >> 7534482

Regulation of the interferon-inducible eIF-2 alpha protein kinase by small RNAs.

M J Clemens¹, K G Laing, I W Jeffrey, A Schofield, T V Sharp, A Elia, V Matys, M C James, V J Tilleray.

Abstract

This review describes the structure and function of the double-stranded RNA-dependent protein kinase (PKR) and its interaction with RNA activators and inhibitors. The abilities of small virally-encoded RNAs such as VAI RNA of adenovirus, the Epstein-Barr virus encoded (EBER) RNAs and the Tat-responsive region RNA of HIV-1 to bind to and regulate PKR are reviewed, and the physiological implications of such regulation for the control of viral replication and cell growth are discussed. The potential effects on the activity of PKR of other proteins that bind double-stranded RNA and/or small viral and cellular RNAs are also considered.

Entities: Gene Species

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Year: 1994 PMID： 7534482 DOI： 10.1016/0300-9084(94)90081-7

Source DB: PubMed Journal: Biochimie ISSN： 0300-9084 Impact factor: 4.079

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Cited

24 in total

8. bic, a novel gene activated by proviral insertions in avian leukosis virus-induced lymphomas, is likely to function through its noncoding RNA.

Authors: W Tam; D Ben-Yehuda; W S Hayward
Journal: Mol Cell Biol Date: 1997-03 Impact factor: 4.272

9. Activation of the dsRNA-dependent protein kinase, PKR, induces apoptosis through FADD-mediated death signaling.

Authors: S Balachandran; C N Kim; W C Yeh; T W Mak; K Bhalla; G N Barber
Journal: EMBO J Date: 1998-12-01 Impact factor: 11.598

10. Murine pancreatic beta TC3 cells show greater 2', 5'-oligoadenylate synthetase (2'5'AS) antiviral enzyme activity and apoptosis following IFN-alpha or poly(I:C) treatment than pancreatic alpha TC3 cells.

Authors: M Li; D-J Zheng; L L Field; V Bonnevie-Nielsen
Journal: Exp Diabetes Res Date: 2009-10-29

Regulation of the interferon-inducible eIF-2 alpha protein kinase by small RNAs.

Review 1. Translational control of viral gene expression in eukaryotes.

2. Straightening of bulged RNA by the double-stranded RNA-binding domain from the protein kinase PKR.

3. A dynamically tuned double-stranded RNA binding mechanism for the activation of antiviral kinase PKR.

4. Phosphorylation of the RNA-dependent protein kinase regulates its RNA-binding activity.

5. The binding site of the RNA-dependent protein kinase (PKR) on EBER1 RNA from Epstein-Barr virus.

6. Protective role of Osthole on myocardial cell apoptosis induced by doxorubicin in rats.

7. PACT, a protein activator of the interferon-induced protein kinase, PKR.

8. bic, a novel gene activated by proviral insertions in avian leukosis virus-induced lymphomas, is likely to function through its noncoding RNA.

9. Activation of the dsRNA-dependent protein kinase, PKR, induces apoptosis through FADD-mediated death signaling.

10. Murine pancreatic beta TC3 cells show greater 2', 5'-oligoadenylate synthetase (2'5'AS) antiviral enzyme activity and apoptosis following IFN-alpha or poly(I:C) treatment than pancreatic alpha TC3 cells.