Literature DB >> 7534237

Chimeric alpha-beta oligonucleotides as antisense inhibitors of reverse transcription.

C Boiziau1, F Debart, B Rayner, J L Imbach, J J Toulme.   

Abstract

Alpha-beta chimeric 17-mer oligodeoxyribonucleotides containing either 5, 10 or 15 beta nucleotides were synthesized. The stability of the RNA/chimera hybrids was only slightly affected by the alpha stretch and by the alpha-beta link, as was the affinity of the Moloney Murine Leukemia Virus reverse transcriptase for the duplexes. All chimeras inhibited in vitro cDNA synthesis in a cell-free system to various extent, via the degradation of the RNA target by RNase H.

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Year:  1995        PMID： 7534237     DOI： 10.1016/0014-5793(95)00138-y

Source DB:  PubMed          Journal:  FEBS Lett        ISSN： 0014-5793            Impact factor:   4.124


  6 in total

1.  Efficient triple helix formation by oligodeoxyribonucleotides containing alpha- or beta-2-amino-5-(2-deoxy-D-ribofuranosyl) pyridine residues.

Authors:  P J Bates; C A Laughton; T C Jenkins; D C Capaldi; P D Roselt; C B Reese; S Neidle
Journal:  Nucleic Acids Res       Date:  1996-11-01       Impact factor: 16.971

2.  alpha-Oligodeoxyribonucleotide N3'-->P5' phosphoramidates: synthesis and duplex formation.

Authors:  K Pongracz; S M Gryaznov
Journal:  Nucleic Acids Res       Date:  1998-02-15       Impact factor: 16.971

3.  Conformational dynamics in mixed alpha/beta-oligonucleotides containing polarity reversals: a molecular dynamics study using time-averaged restraints.

Authors:  J M Aramini; A Mujeeb; N B Ulyanov; M W Germann
Journal:  J Biomol NMR       Date:  2000-12       Impact factor: 2.835

4.  Phosphorothioate oligonucleotides derived from human immunodeficiency virus type 1 (HIV-1) primer tRNALys3 are strong inhibitors of HIV-1 reverse transcriptase and arrest viral replication in infected cells.

Authors:  R El Dirani-Diab; L Sarih-Cottin; B Delord; B Dumon; S Moreau; J J Toulme; H Fleury; S Litvak
Journal:  Antimicrob Agents Chemother       Date:  1997-10       Impact factor: 5.191

5.  7',5'-alpha-bicyclo-DNA: new chemistry for oligonucleotide exon splicing modulation therapy.

Authors:  Damien Evéquoz; Ingrid E C Verhaart; Davy van de Vijver; Wolfgang Renner; Annemieke Aartsma-Rus; Christian J Leumann
Journal:  Nucleic Acids Res       Date:  2021-12-02       Impact factor: 16.971

Review 6.  Review of α-nucleosides: from discovery, synthesis to properties and potential applications.

Authors:  Guangcheng Ni; Yuqi Du; Fan Tang; Jiang Liu; Hang Zhao; Qianming Chen
Journal:  RSC Adv       Date:  2019-05-07       Impact factor: 4.036
  6 in total

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