Literature DB >> 7533559

Early phosphorylation of tau in Alzheimer's disease occurs at Ser-202 and is preferentially located within neurites.

J H Su1, B J Cummings, C W Cotman.   

Abstract

Within the neurofibrillary tangles (NFTs) and dystrophic neurites (DNs) of Alzheimer's disease (AD), the cytoskeletal protein tau is abnormally hyperphosphorylated. In this study we evaluate the phosphorylation of specific residues on tau within different phases of the formation of NFTs. Two monoclonal antibodies, AT8 and PHF-1, were used to selectively recognize phosphorylated Ser-202 and Ser-396 of PHF-tau protein, respectively. We found that abnormal phosphorylation of tau appears to occur first at Ser-202 in DNs, then at Ser-202 in the soma and finally at Ser-396 in DNs and NFTs. These results suggest that abnormal phosphorylation at Ser-202 of PHF-tau in DNs represents one of the earliest neuropathological changes within the neurites of vulnerable neurons and may have a pivotal role in the initial pathogenesis of AD.

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Year:  1994        PMID： 7533559     DOI： 10.1097/00001756-199411000-00037

Source DB:  PubMed          Journal:  Neuroreport        ISSN： 0959-4965            Impact factor:   1.837


  30 in total

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4.  Frontal cortex neuropathology in dementia pugilistica.

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5.  Regional distribution of amyloid-Bri deposition and its association with neurofibrillary degeneration in familial British dementia.

Authors:  J L Holton; J Ghiso; T Lashley; A Rostagno; C J Guerin; G Gibb; H Houlden; H Ayling; L Martinian; B H Anderton; N W Wood; R Vidal; G Plant; B Frangione; T Revesz
Journal:  Am J Pathol       Date:  2001-02       Impact factor: 4.307

6.  C-terminal fragments of amyloid-beta peptide cause cholinergic axonal degeneration by a toxic effect rather than by physical injury in the nondemented human brain.

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8.  Cholinergic Differentiation of Human Neuroblastoma SH-SY5Y Cell Line and Its Potential Use as an In vitro Model for Alzheimer's Disease Studies.

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Review 9.  Leptin: a novel therapeutic strategy for Alzheimer's disease.

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Review 10.  Chronic traumatic encephalopathy in athletes: progressive tauopathy after repetitive head injury.

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