Literature DB >> 7533118

Sequence of the functional human keratin K14 promoter.

W R Staggers1, A J Paterson, J E Kudlow.   

Abstract

The K14 keratin is an intermediate filament produced in squamous epithelia. This tissue-specific expression is directed by the promoter (pK14) of the K14 gene which has been used extensively to direct the expression of transgenes to the skin. Human K14 was cloned and the upstream sequence is presented. In transient transfections, pK14 directs expression of a luciferase reporter in keratinocytes much more potently than in breast cancer cells.

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Year:  1995        PMID： 7533118     DOI： 10.1016/0378-1119(94)00731-7

Source DB:  PubMed          Journal:  Gene        ISSN： 0378-1119            Impact factor:   3.688


  4 in total

1.  The design and optimization of RNA trans-splicing molecules for skin cancer therapy.

Authors:  Christina Gruber; Ulrich Koller; Eva M Murauer; Stefan Hainzl; Clemens Hüttner; Thomas Kocher; Andrew P South; Helmut Hintner; Johann W Bauer
Journal:  Mol Oncol       Date:  2013-08-19       Impact factor: 6.603

2.  Keratin-6 driven ODC expression to hair follicle keratinocytes enhances stemness and tumorigenesis by negatively regulating Notch.

Authors:  Aadithya Arumugam; Zhiping Weng; Sandeep C Chaudhary; Farrukh Afaq; Craig A Elmets; Mohammad Athar
Journal:  Biochem Biophys Res Commun       Date:  2014-08-02       Impact factor: 3.575

3.  Keratinocyte-targeted expression of human laminin γ2 rescues skin blistering and early lethality of laminin γ2 deficient mice.

Authors:  Tracy L Adair-Kirk; Gail L Griffin; Michelle J Meyer; Diane G Kelley; Jeffrey H Miner; Douglas R Keene; M Peter Marinkovich; J Michael Ruppert; Jouni Uitto; Robert M Senior
Journal:  PLoS One       Date:  2012-09-18       Impact factor: 3.240

4.  Minimally invasive microbiopsies: a novel sampling method for identifying asymptomatic, potentially infectious carriers of Leishmania donovani.

Authors:  Oscar David Kirstein; Ibrahim Abbasi; Ben Zion Horwitz; Laura Skrip; Asrat Hailu; Charles Jaffe; Lynlee L Li; Tarl W Prow; Alon Warburg
Journal:  Int J Parasitol       Date:  2017-04-26       Impact factor: 3.981
  4 in total

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