Literature DB >> 7532861

Preparation of sterically stabilized human serum albumin nanospheres using a novel Dextranox-MPEG crosslinking agent.

W Lin1, A G Coombes, M C Garnett, M C Davies, E Schacht, S S Davis, L Illum.   

Abstract

Human serum albumin (HSA) nanospheres with a size less than 200 nm in diameter were prepared using a modified coacervation method and crosslinking with methyl polyethylene glycol modified oxidized Dextram (Dextranox-MPEG) which created a sterically stabilizing polyethylene oxide surface layer surrounding the nanospheres. The crosslinking efficiency and the surface characteristics of glutaraldehyde and Dextranox-MPEG crosslinked HSA nanospheres were determined and compared. The zeta potential of the Dextranox-MPEG crosslinked particles was significantly lower than that of glutaraldehyde stabilized particles. The existence of a hydrated steric barrier surrounding the nanospheres was confirmed by an electrolyte and pH induced flocculation test. The Dextranox-MPEG crosslinked nanospheres showed a significantly reduced plasma protein adsorption on the particle surface compared with glutaraldehyde crosslinked nanospheres.

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Year:  1994        PMID： 7532861     DOI： 10.1023/a:1018957704209

Source DB:  PubMed          Journal:  Pharm Res        ISSN： 0724-8741            Impact factor:   4.200


  9 in total

1.  The polyoxyethylene/polyoxypropylene block co-polymer poloxamer-407 selectively redirects intravenously injected microspheres to sinusoidal endothelial cells of rabbit bone marrow.

Authors:  C J Porter; S M Moghimi; L Illum; S S Davis
Journal:  FEBS Lett       Date:  1992-06-22       Impact factor: 4.124

2.  Tissue specific opsonins for phagocytic cells and their different affinity for cholesterol-rich liposomes.

Authors:  S M Moghimi; H M Patel
Journal:  FEBS Lett       Date:  1988-06-06       Impact factor: 4.124

Review 3.  Chemical cross-linking: reagents and problems in studies of membrane structure.

Authors:  K Peters; F M Richards
Journal:  Annu Rev Biochem       Date:  1977       Impact factor: 23.643

4.  Non-phagocytic uptake of intravenously injected microspheres in rat spleen: influence of particle size and hydrophilic coating.

Authors:  S M Moghimi; C J Porter; I S Muir; L Illum; S S Davis
Journal:  Biochem Biophys Res Commun       Date:  1991-06-14       Impact factor: 3.575

5.  An investigation of the filtration capacity and the fate of large filtered sterically-stabilized microspheres in rat spleen.

Authors:  S M Moghimi; H Hedeman; I S Muir; L Illum; S S Davis
Journal:  Biochim Biophys Acta       Date:  1993-07-11

6.  Coating particles with a block co-polymer (poloxamine-908) suppresses opsonization but permits the activity of dysopsonins in the serum.

Authors:  S M Moghimi; I S Muir; L Illum; S S Davis; V Kolb-Bachofen
Journal:  Biochim Biophys Acta       Date:  1993-11-07

7.  Preparation of human serum albumin microspheres by a novel acetone-heat denaturation method.

Authors:  C Q Chen; W Lin; A G Coombes; S S Davis; L Illum
Journal:  J Microencapsul       Date:  1994 Jul-Aug       Impact factor: 3.142

8.  Human serum albumin as a probe for surface conditioning (opsonization) of block copolymer-coated microspheres.

Authors:  M E Norman; P Williams; L Illum
Journal:  Biomaterials       Date:  1992       Impact factor: 12.479

9.  Preparation of sub-100 nm human serum albumin nanospheres using a pH-coacervation method.

Authors:  W Lin; A G Coombes; M C Davies; S S Davis; L Illum
Journal:  J Drug Target       Date:  1993       Impact factor: 5.121
  9 in total
  5 in total

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Journal:  AAPS PharmSciTech       Date:  2005-09-30       Impact factor: 3.246

4.  Metoclopramide nanoparticles modulate immune response in a diabetic rat model: association with regulatory T cells and proinflammatory cytokines.

Authors:  Noura H Abd Ellah; Esraa A Ahmed; Rasha B Abd-Ellatief; Marwa F Ali; Asmaa M Zahran; Helal F Hetta
Journal:  Int J Nanomedicine       Date:  2019-04-03

5.  Mitotic and antiapoptotic effects of nanoparticles coencapsulating human VEGF and human angiopoietin-1 on vascular endothelial cells.

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Journal:  Int J Nanomedicine       Date:  2011-05-24
  5 in total

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