| Literature DB >> 7532613 |
L E Underwood1, J P Thissen, S Lemozy, J M Ketelslegers, D R Clemmons.
Abstract
The influence of nutrition on growth seems likely to be mediated in part through IGF-I. Restriction of dietary nutrients adversely effects IGF-I synthesis and action at multiple steps, including decreased GH receptors, postreceptor defects in GH action, decreased steady state levels of IGF-I mRNA, and attenuation of IGF-I action. In addition, undernutrition affects the IGF binding proteins in ways that vary from one tissue to another. Understanding the alterations in IGFBPs that are caused by nutritional insufficiency may provide insight into the actions of the IGFBPs.Entities:
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Year: 1994 PMID： 7532613 DOI： 10.1159/000184187
Source DB: PubMed Journal: Horm Res ISSN： 0301-0163