Literature DB >> 7530877

Synuclein proteins and Alzheimer's disease.

A J Brookes1, D St Clair.   

Abstract

In Alzheimer's disease, synuclein/NAC (non-amyloid beta component of Alzheimer's disease amyloid) proteins are found in presynaptic cholinergic nerve terminals that degenerate early in Alzheimer's disease, and they are also found closely linked to beta-amyloid fibrils in senile plaques. Synuclein/NAC proteins provide a potential molecular link between the degeneration of cholinergic nerve terminals, and the formation of plaques, and might have a primary role in their development.

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Year:  1994        PMID： 7530877     DOI： 10.1016/0166-2236(94)90013-2

Source DB:  PubMed          Journal:  Trends Neurosci        ISSN： 0166-2236            Impact factor:   13.837


  8 in total

Review 1.  Protein aggregates and dementia: is there a common toxicity?

Authors:  S Lovestone; D M McLoughlin
Journal:  J Neurol Neurosurg Psychiatry       Date:  2002-02       Impact factor: 10.154

Review 2.  The toxicity in vitro of beta-amyloid protein.

Authors:  L L Iversen; R J Mortishire-Smith; S J Pollack; M S Shearman
Journal:  Biochem J       Date:  1995-10-01       Impact factor: 3.857

3.  Residues in the synuclein consensus motif of the alpha-synuclein fragment, NAC, participate in transglutaminase-catalysed cross-linking to Alzheimer-disease amyloid beta A4 peptide.

Authors:  P H Jensen; E S Sørensen; T E Petersen; J Gliemann; L K Rasmussen
Journal:  Biochem J       Date:  1995-08-15       Impact factor: 3.857

4.  The first N-terminal amino acids of alpha-synuclein are essential for alpha-helical structure formation in vitro and membrane binding in yeast.

Authors:  Katherina Vamvaca; Michael J Volles; Peter T Lansbury
Journal:  J Mol Biol       Date:  2009-03-13       Impact factor: 5.469

5.  Tissue transglutaminase, protein cross-linking and Alzheimer's disease: review and views.

Authors:  Deng-Shun Wang; Dennis W Dickson; James S Malter
Journal:  Int J Clin Exp Pathol       Date:  2008-01-01

6.  Comparisons of the NACP self-oligomerizations induced by Abeta25-35 in the presence of dicyclohexylcarbodiimide and N-(ethoxycarbonyl)-2-ethoxy-1,2-dihydroquinoline.

Authors:  J H Lee; H J Shin; C S Chang; S R Paik
Journal:  Neurochem Res       Date:  1998-11       Impact factor: 3.996

Review 7.  The Neurodegenerative Elderly Syndrome (NES) hypothesis: Alzheimer and Parkinson are two faces of the same disease.

Authors:  Daniele Caligiore; Flora Giocondo; Massimo Silvetti
Journal:  IBRO Neurosci Rep       Date:  2022-09-26

Review 8.  Amyloids: Regulators of Metal Homeostasis in the Synapse.

Authors:  Masahiro Kawahara; Midori Kato-Negishi; Ken-Ichiro Tanaka
Journal:  Molecules       Date:  2020-03-23       Impact factor: 4.411
  8 in total

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