Literature DB >> 7530393

Enhancement of HIV-1 proteinase activity by HIV-1 reverse transcriptase.

L Goobar-Larsson1, B G Luukkonen, T Unge, S Schwartz, G Utter, B Strandberg, B Oberg.   

Abstract

HIV-1 reverse transcriptase (RT) was found to increase the activity of HIV-1 proteinase in vitro and in eukaryotic cells. The effect of RT on proteinase activity was dose-dependent and independent of pH or salt concentration. The cleavage of sequences corresponding to all the naturally occurring cleavage sites that could be tested in vitro was enhanced. The effect of RT on cleavage was greatest at the cleavage site between RT and integrase. The enhancement of viral proteinase activity by the virus RT may contribute to regulation of the order and/or efficiency of cleavage at different sites during virus replication and maturation.

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Year:  1995        PMID： 7530393     DOI： 10.1016/s0042-6822(95)80054-9

Source DB:  PubMed          Journal:  Virology        ISSN： 0042-6822            Impact factor:   3.616


  5 in total

1.  Human immunodeficiency virus type 1 (HIV-1) protein Vif inhibits the activity of HIV-1 protease in bacteria and in vitro.

Authors:  M Kotler; M Simm; Y S Zhao; P Sova; W Chao; S F Ohnona; R Roller; C Krachmarov; M J Potash; D J Volsky
Journal:  J Virol       Date:  1997-08       Impact factor: 5.103

2.  HIV-1 protease inhibits its homologous reverse transcriptase by protein-protein interaction.

Authors:  M Böttcher; F Grosse
Journal:  Nucleic Acids Res       Date:  1997-05-01       Impact factor: 16.971

Review 3.  HIV Genome-Wide Protein Associations: a Review of 30 Years of Research.

Authors:  Guangdi Li; Erik De Clercq
Journal:  Microbiol Mol Biol Rev       Date:  2016-06-29       Impact factor: 11.056

4.  Conserved cysteines of the human immunodeficiency virus type 1 protease are involved in regulation of polyprotein processing and viral maturation of immature virions.

Authors:  D A Davis; K Yusa; L A Gillim; F M Newcomb; H Mitsuya; R Yarchoan
Journal:  J Virol       Date:  1999-02       Impact factor: 5.103

5.  Binding interface and impact on protease cleavage for an RNA aptamer to HIV-1 reverse transcriptase.

Authors:  Phuong D M Nguyen; Jie Zheng; Thomas J Gremminger; Liming Qiu; Dong Zhang; Steve Tuske; Margaret J Lange; Patrick R Griffin; Eddy Arnold; Shi-Jie Chen; Xiaoqin Zou; Xiao Heng; Donald H Burke
Journal:  Nucleic Acids Res       Date:  2020-03-18       Impact factor: 16.971
  5 in total

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