Literature DB >> 7529048

The insulin-like growth factor I receptor gene is the target for the 15q26 amplicon in breast cancer.

A Almeida1, M Muleris, B Dutrillaux, B Malfoy.   

Abstract

We report the amplification and overexpression of the IGFIR (insulin-like growth factor I receptor) gene in primary breast cancers with an amplification of band 15q26. The involvement of IGFIR, which may vary in frequency from 2-3% in unselected tumor series to more than 10% in breast cancers with hsr, may represent an important event in tumor progression.

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Year:  1994        PMID： 7529048     DOI： 10.1002/gcc.2870110110

Source DB:  PubMed          Journal:  Genes Chromosomes Cancer        ISSN： 1045-2257            Impact factor:   5.006


  14 in total

Review 1.  Roles for growth factors in cancer progression.

Authors:  Esther Witsch; Michael Sela; Yosef Yarden
Journal:  Physiology (Bethesda)       Date:  2010-04

2.  The insulin-like growth factor I receptor is required for Akt activation and suppression of anoikis in cells transformed by the ETV6-NTRK3 chimeric tyrosine kinase.

Authors:  Matthew J Martin; Nataliya Melnyk; Michelle Pollard; Mary Bowden; Hon Leong; Thomas J Podor; Martin Gleave; Poul H B Sorensen
Journal:  Mol Cell Biol       Date:  2006-03       Impact factor: 4.272

3.  IGF gene polymorphisms and breast cancer in African-American and Hispanic women.

Authors:  Marianna Sarkissyan; Dhruva Kumar Mishra; Yanyuan Wu; Xiying Shang; Suren Sarkissyan; Jaydutt V Vadgama
Journal:  Int J Oncol       Date:  2011-03-30       Impact factor: 5.650

4.  CKS1BP7, a Pseudogene of CKS1B, is Co-Amplified with IGF1R in Breast Cancers.

Authors:  Yansong Liu; Wei Wang; Yan Li; Feifei Sun; Jiaxiang Lin; Li Li
Journal:  Pathol Oncol Res       Date:  2017-04-24       Impact factor: 3.201

5.  PTK6 regulates IGF-1-induced anchorage-independent survival.

Authors:  Hanna Y Irie; Yashaswi Shrestha; Laura M Selfors; Fabianne Frye; Naoko Iida; Zhigang Wang; Lihua Zou; Jun Yao; Yiling Lu; Charles B Epstein; Sridaran Natesan; Andrea L Richardson; Kornelia Polyak; Gordon B Mills; William C Hahn; Joan S Brugge
Journal:  PLoS One       Date:  2010-07-23       Impact factor: 3.240

6.  IGF-IR and its inhibitors in gastrointestinal carcinomas (Review).

Authors:  Xiao Hong Bao; Yoshio Naomoto; Hui Fang Hao; Nobuyuki Watanabe; Kazufumi Sakurama; Kazuhiro Noma; Takayuki Motoki; Yasuko Tomono; Takuya Fukazawa; Yasuhiro Shirakawa; Tomoki Yamatsuji; Junji Matsuoka; Munenori Takaoka
Journal:  Oncol Lett       Date:  2010-01-01       Impact factor: 2.967

7.  MicroRNA-214 Reduces Insulin-like Growth Factor-1 (IGF-1) Receptor Expression and Downstream mTORC1 Signaling in Renal Carcinoma Cells.

Authors:  Falguni Das; Nirmalya Dey; Amit Bera; Balakuntalam S Kasinath; Nandini Ghosh-Choudhury; Goutam Ghosh Choudhury
Journal:  J Biol Chem       Date:  2016-05-13       Impact factor: 5.157

8.  Insulin-like growth factor 1 receptor is a potential therapeutic target for gastrointestinal stromal tumors.

Authors:  Chi Tarn; Lori Rink; Erin Merkel; Douglas Flieder; Harsh Pathak; Daphne Koumbi; Joseph R Testa; Burton Eisenberg; Margaret von Mehren; Andrew K Godwin
Journal:  Proc Natl Acad Sci U S A       Date:  2008-06-11       Impact factor: 11.205

Review 9.  Elevated PI3K signaling drives multiple breast cancer subtypes.

Authors:  Jessica R Adams; Nathan F Schachter; Jeff C Liu; Eldad Zacksenhaus; Sean E Egan
Journal:  Oncotarget       Date:  2011-06

10.  Dual targeting of the insulin-like growth factor and collateral pathways in cancer: combating drug resistance.

Authors:  Joseph A Ludwig; Salah-Eddine Lamhamedi-Cherradi; Ho-Young Lee; Aung Naing; Robert Benjamin
Journal:  Cancers (Basel)       Date:  2011-07-26       Impact factor: 6.639
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