Literature DB >> 7526655

Role of positive charges of neuropeptide Y fragments in mast cell activation.

M Mousli1, Y Landry.   

Abstract

The incubation of neuropeptide Y (NPY) or of NPY C-terminal fragments with rat peritoneal mast cells resulted in a dose-dependent histamine secretion (10(-9)-10(-5) M). A linear correlation between the number of net positive charges of the peptides and histamine release potencies was obtained. The histamine secretion induced by NPY fragments was inhibited by the treatment of mast cells with benzalkonium chloride and pertussis toxin indicating the involvement of G proteins.

Entities:  

Mesh：

Substances：

Year:  1994        PMID： 7526655     DOI： 10.1007/bf02007758

Source DB:  PubMed          Journal:  Agents Actions        ISSN： 0065-4299


  8 in total

1.  Regulation of Gi and Go by mastoparan, related amphiphilic peptides, and hydrophobic amines. Mechanism and structural determinants of activity.

Authors:  T Higashijima; J Burnier; E M Ross
Journal:  J Biol Chem       Date:  1990-08-25       Impact factor: 5.157

Review 2.  G protein activation: a receptor-independent mode of action for cationic amphiphilic neuropeptides and venom peptides.

Authors:  M Mousli; J L Bueb; C Bronner; B Rouot; Y Landry
Journal:  Trends Pharmacol Sci       Date:  1990-09       Impact factor: 14.819

3.  Structure of neuropeptide Y dimer in solution.

Authors:  D J Cowley; J M Hoflack; J T Pelton; V Saudek
Journal:  Eur J Biochem       Date:  1992-05-01

4.  Neuropeptide Y, peptide YY and C-terminal fragments release histamine from rat peritoneal mast cells.

Authors:  L Grundemar; R Håkanson
Journal:  Br J Pharmacol       Date:  1991-12       Impact factor: 8.739

Review 5.  Neuropeptide Y-related peptides and their receptors--are the receptors potential therapeutic drug targets?

Authors:  C Wahlestedt; D J Reis
Journal:  Annu Rev Pharmacol Toxicol       Date:  1993       Impact factor: 13.820

6.  Neuropeptide Y--a novel brain peptide with structural similarities to peptide YY and pancreatic polypeptide.

Authors:  K Tatemoto; M Carlquist; V Mutt
Journal:  Nature       Date:  1982-04-15       Impact factor: 49.962

7.  Activation of rat peritoneal mast cells by substance P and mastoparan.

Authors:  M Mousli; C Bronner; J L Bueb; E Tschirhart; J P Gies; Y Landry
Journal:  J Pharmacol Exp Ther       Date:  1989-07       Impact factor: 4.030

8.  The mechanism of inhibition of alkylamines on the mast-cell peptidergic pathway.

Authors:  T Fischer; C Bronner; Y Landry; M Mousli
Journal:  Biochim Biophys Acta       Date:  1993-04-16
  8 in total
  1 in total

1.  Role of G-proteins in peptidergic activation of both human and rat cutaneous mast cells.

Authors:  B Emadi-Khiav; M Mousli; Y Landry
Journal:  Inflamm Res       Date:  1995-04       Impact factor: 4.575
  1 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.