Literature DB >> 7525127

Treatment of linear localized scleroderma with the anti-allergic drug, tranilast.

S Taniguchi1, T Yorifuji, T Hamada.   

Abstract

A 14-year-old boy with linear localized scleroderma had a dramatic improvement in contractures after treatment with N-(3',4'-dimethoxycinnamoyl) anthranilic acid (tranilast, Rizaben). The observation that this anti-allergic drug was effective in localized scleroderma lends further support to the concept that mast cells play a role in increased collagen synthesis in this disease.

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Year:  1994        PMID： 7525127     DOI： 10.1111/j.1365-2230.1994.tb02689.x

Source DB:  PubMed          Journal:  Clin Exp Dermatol        ISSN： 0307-6938            Impact factor:   3.470


  7 in total

Review 1.  The Atrium in Atrial Fibrillation - A Clinical Review on How to Manage Atrial Fibrotic Substrates.

Authors:  Pedro Silva Cunha; Sérgio Laranjo; Jordi Heijman; Mário Martins Oliveira
Journal:  Front Cardiovasc Med       Date:  2022-07-04

2.  Immunohistochemical studies of the kynurenine pathway in morphea.

Authors:  Rowland Noakes; Nick Mellick
Journal:  Int J Tryptophan Res       Date:  2013-12-23

3.  Late onset oral treatment with tranilast following large myocardial infarction has no beneficial effects on cardiac remodeling and mortality in rats.

Authors:  Stefan Betge; Christian Kunz; Hans Figulla; Christian Jung
Journal:  Exp Ther Med       Date:  2014-10-06       Impact factor: 2.447

4.  Tranilast Can be a Useful Addition to the Limited Anti-Epidermolysis Bullosa Weaponry.

Authors:  Mohammad Mahdi Parvizi; Mohammad Reza Namazi
Journal:  Adv Pharm Bull       Date:  2017-04-13

5.  Effects of tranilast on the epithelial-to-mesenchymal transition in peritoneal mesothelial cells.

Authors:  Seok Hui Kang; Sang Woon Kim; Keuk Jun Kim; Kyu Hyang Cho; Jong Won Park; Chan-Duck Kim; Jun Young Do
Journal:  Kidney Res Clin Pract       Date:  2019-12-31

6.  Effects of tranilast on the urinary excretion of kynurenic and quinolinic Acid under conditions of L tryptophan loading.

Authors:  Rowland R Noakes
Journal:  Int J Tryptophan Res       Date:  2013-09-22

7.  Assessing the response of morphea and limited scleroderma to tranilast: a small prospective study comparing topical corticosteroids to a combination of topical corticosteroids and tranilast.

Authors:  Rowland Noakes
Journal:  Clin Cosmet Investig Dermatol       Date:  2018-07-04
  7 in total

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