Literature DB >> 752458

The finite dose technique as a valid in vitro model for the study of percutaneous absorption in man.

T J Franz.   

Abstract

An in vitro model of percutaneous absorption has been developed which permits close stimulation of conditions commonly associated with topical drug use in living man. Quantitative comparison of the absorption of selected compounds in the model and in living man was made to test the validity of the model. Excellent agreement has been found between the two sets of data, both with respect to the total amount absorbed and the kinetics of absorption.

Entities:  

Mesh：

Substances：

Year:  1978        PMID： 752458     DOI： 10.1159/000401276

Source DB:  PubMed          Journal:  Curr Probl Dermatol        ISSN： 1421-5721


  15 in total

1.  Validation of a static Franz diffusion cell system for in vitro permeation studies.

Authors:  Shiow-Fern Ng; Jennifer J Rouse; Francis D Sanderson; Victor Meidan; Gillian M Eccleston
Journal:  AAPS PharmSciTech       Date:  2010-09-15       Impact factor: 3.246

2.  Percutaneous absorption and metabolism of aldrin by rat skin in diffusion cells.

Authors:  S E Macpherson; R C Scott; F M Williams
Journal:  Arch Toxicol       Date:  1991       Impact factor: 5.153

Review 3.  Modeling kinetics of subcellular disposition of chemicals.

Authors:  Stefan Balaz
Journal:  Chem Rev       Date:  2009-05       Impact factor: 60.622

4.  The bioavailability of dermatological and other topically administered drugs.

Authors:  R H Guy; A H Guy; H I Maibach; V P Shah
Journal:  Pharm Res       Date:  1986-10       Impact factor: 4.200

5.  Use of excised human skin to assess the bioequivalence of topical products.

Authors:  T J Franz; P A Lehman; S G Raney
Journal:  Skin Pharmacol Physiol       Date:  2009-08-26       Impact factor: 3.479

6.  In vitro absorption of some chlorinated paraffins through human skin.

Authors:  R C Scott
Journal:  Arch Toxicol       Date:  1989       Impact factor: 5.153

7.  The effect of ultrasound on the in vitro penetration of ibuprofen through human epidermis.

Authors:  R Brucks; M Nanavaty; D Jung; F Siegel
Journal:  Pharm Res       Date:  1989-08       Impact factor: 4.200

8.  Alkane-induced edema formation and cutaneous barrier dysfunction.

Authors:  S J Moloney; J J Teal
Journal:  Arch Dermatol Res       Date:  1988       Impact factor: 3.017

9.  Entrapment of ketorolac tromethamine in polymeric vehicle for controlled drug delivery.

Authors:  S K Paliwal; Rajani Chauhan; Veena Sharma; D K Majumdar; S Paliwal
Journal:  Indian J Pharm Sci       Date:  2009-11       Impact factor: 0.975

10.  The Tritiated Water Skin Barrier Integrity Test: Considerations for Acceptance Criteria with and Without 14C-Octanol.

Authors:  Paul A Lehman; Kacie Beatch; Sam G Raney; Thomas J Franz
Journal:  Pharm Res       Date:  2016-11-07       Impact factor: 4.200
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.