Literature DB >> 7523640

Co-expression of endothelial cell and macrophage antigens in Kaposi's sarcoma cells.

S Uccini1, L P Ruco, F Monardo, A Stoppacciaro, E Dejana, I L La Parola, D Cerimele, C D Baroni.   

Abstract

The histopathogenesis of Kaposi's sarcoma (KS) was investigated using immunocytochemistry in 12 skin biopsies obtained from two AIDS patients, nine patients with the classic form, and one organ-transplant patient. KS cells revealed a peculiar antigenic profile, being characterized by co-expression of endothelial and macrophage markers. KS cells were stained for von Willebrand factor (vWF); for vascular endothelial (VE) cadherin, an endothelial specific adhesion molecule; and for PECAM/CD31. In addition, they expressed the macrophage antigens PAM-1, CD68, and CD14, and were positive for vitronectin receptor and alpha-1,5,6/beta-1 integrins. KS cells were weakly stained for ICAM-1 in 6 of 12 cases and were negative for VCAM-1 and E-selectin.

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Year:  1994        PMID： 7523640     DOI： 10.1002/path.1711730105

Source DB:  PubMed          Journal:  J Pathol        ISSN： 0022-3417            Impact factor:   7.996


  21 in total

1.  Capillary endothelial cell tropism of PVC-211 murine leukemia virus and its application for gene transduction.

Authors:  M Masuda; C A Hanson; N V Dugger; D S Robbins; S G Wilt; S K Ruscetti; P M Hoffman
Journal:  J Virol       Date:  1997-08       Impact factor: 5.103

Review 2.  Molecular biology of KSHV in relation to AIDS-associated oncogenesis.

Authors:  Whitney Greene; Kurt Kuhne; Fengchun Ye; Jiguo Chen; Fuchun Zhou; Xiufen Lei; Shou-Jiang Gao
Journal:  Cancer Treat Res       Date:  2007

3.  Kaposi sarcoma herpesvirus K5 removes CD31/PECAM from endothelial cells.

Authors:  Mandana Mansouri; Janet Douglas; Patrick P Rose; Kristine Gouveia; Gary Thomas; Robert E Means; Ashlee V Moses; Klaus Früh
Journal:  Blood       Date:  2006-04-06       Impact factor: 22.113

4.  Endothelin receptor blockade inhibits proliferation of Kaposi's sarcoma cells.

Authors:  A Bagnato; L Rosanò; V Di Castro; A Albini; D Salani; M Varmi; M R Nicotra; P G Natali
Journal:  Am J Pathol       Date:  2001-03       Impact factor: 4.307

5.  Altered patterns of cellular gene expression in dermal microvascular endothelial cells infected with Kaposi's sarcoma-associated herpesvirus.

Authors:  Lynn J Poole; Yanxing Yu; Peter S Kim; Qi-Zhi Zheng; Jonathan Pevsner; Gary S Hayward
Journal:  J Virol       Date:  2002-04       Impact factor: 5.103

6.  Kaposi's sarcoma cells express the macrophage-associated antigen mannose receptor and develop in peripheral blood cultures of Kaposi's sarcoma patients.

Authors:  S Uccini; M C Sirianni; L Vincenzi; S Topino; A Stoppacciaro; I Lesnoni La Parola; M Capuano; C Masini; D Cerimele; M Cella; A Lanzavecchia; P Allavena; A Mantovani; C D Baroni; L P Ruco
Journal:  Am J Pathol       Date:  1997-03       Impact factor: 4.307

7.  Long-term infection and transformation of dermal microvascular endothelial cells by human herpesvirus 8.

Authors:  A V Moses; K N Fish; R Ruhl; P P Smith; J G Strussenberg; L Zhu; B Chandran; J A Nelson
Journal:  J Virol       Date:  1999-08       Impact factor: 5.103

8.  Kaposin-B enhances the PROX1 mRNA stability during lymphatic reprogramming of vascular endothelial cells by Kaposi's sarcoma herpes virus.

Authors:  Jaehyuk Yoo; Jinjoo Kang; Ha Neul Lee; Berenice Aguilar; Darren Kafka; Sunju Lee; Inho Choi; Juneyong Lee; Swapnika Ramu; Juergen Haas; Chester J Koh; Young-Kwon Hong
Journal:  PLoS Pathog       Date:  2010-08-12       Impact factor: 6.823

9.  KSHV/HHV-8 infection of human hematopoietic progenitor (CD34+) cells: persistence of infection during hematopoiesis in vitro and in vivo.

Authors:  William Wu; Jeffrey Vieira; Nancy Fiore; Prabal Banerjee; Michelle Sieburg; Rosemary Rochford; William Harrington; Gerold Feuer
Journal:  Blood       Date:  2006-03-16       Impact factor: 22.113

10.  Elevation of soluble intercellular adhesion molecule-1 levels, but not angiopoietin 2, in the plasma of human immunodeficiency virus-infected African women with clinical Kaposi sarcoma.

Authors:  Susan M Graham; Nimerta Rajwans; Barbra A Richardson; Walter Jaoko; R Scott McClelland; Julie Overbaugh; W Conrad Liles
Journal:  Am J Trop Med Hyg       Date:  2014-07-07       Impact factor: 2.345
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