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Literature DB >> 7523351

Synthetic oligonucleotides with certain palindromes stimulate interferon production of human peripheral blood lymphocytes in vitro.

T Yamamoto¹, S Yamamoto, T Kataoka, K Komuro, M Kohase, T Tokunaga.

Abstract

We studied the ability of synthetic single-stranded 30-mer oligodeoxyribonucleotides (oligoDNAs) with three different kinds of hexamer palindromic sequence to induce interferon (IFN) production of human peripheral blood lymphocytes (PBL). When PBL was cultured with oligoDNA having a palindrome of AACGTT or GACGTC, IFN activity was detected by bioassay in the culture fluid after 8 h, and the amount of IFN reached the maximum after 18 h. IFN-alpha was predominantly produced, and small amounts of IFN-beta and IFN-gamma were also found. OligoDNA with the palindrome ACCGGT had no effect.

Entities: Chemical Disease Gene Species

Mesh：

Substances：

Year: 1994 PMID： 7523351 PMCID： PMC5919569 DOI： 10.1111/j.1349-7006.1994.tb02947.x

Source DB: PubMed Journal: Jpn J Cancer Res ISSN： 0910-5050

16 in total

1. In vitro augmentation of natural killer activity of peripheral blood cells from cancer patients by a DNA fraction from Mycobacterium bovis BCG.

Authors: H Mashiba; K Matsunaga; H Tomoda; M Furusawa; S Jimi; T Tokunaga
Journal: Jpn J Med Sci Biol Date: 1988 Oct-Dec

2. In vivo augmentation of natural killer cell activity with a deoxyribonucleic acid fraction of BCG.

Authors: S Shimada; O Yano; T Tokunaga
Journal: Jpn J Cancer Res Date: 1986-08

3. DNA binding to human leukocytes. Evidence for a receptor-mediated association, internalization, and degradation of DNA.

Authors: R M Bennett; G T Gabor; M M Merritt
Journal: J Clin Invest Date: 1985-12 Impact factor: 14.808

4. Cloning and expression of the Mycobacterium bovis BCG gene for extracellular alpha antigen.

Authors: K Matsuo; R Yamaguchi; A Yamazaki; H Tasaka; T Yamada
Journal: J Bacteriol Date: 1988-09 Impact factor: 3.490

5. Mechanism of oligonucleotide uptake by cells: involvement of specific receptors?

Authors: L A Yakubov; E A Deeva; V F Zarytova; E M Ivanova; A S Ryte; L V Yurchenko; V V Vlassov
Journal: Proc Natl Acad Sci U S A Date: 1989-09 Impact factor: 11.205

6. Characterization, sequence determination, and immunogenicity of a 64-kilodalton protein of Mycobacterium bovis BCG expressed in escherichia coli K-12.

Authors: J E Thole; W J Keulen; J De Bruyn; A H Kolk; D G Groothuis; L G Berwald; R H Tiesjema; J D van Embden
Journal: Infect Immun Date: 1987-06 Impact factor: 3.441

7. Unique palindromic sequences in synthetic oligonucleotides are required to induce IFN [correction of INF] and augment IFN-mediated [correction of INF] natural killer activity.

Authors: S Yamamoto; T Yamamoto; T Kataoka; E Kuramoto; O Yano; T Tokunaga
Journal: J Immunol Date: 1992-06-15 Impact factor: 5.422

8. Antitumor activity of the DNA fraction from Mycobacterium bovis BCG. II. Effects on various syngeneic mouse tumors.

Authors: S Shimada; O Yano; H Inoue; E Kuramoto; T Fukuda; H Yamamoto; T Kataoka; T Tokunaga
Journal: J Natl Cancer Inst Date: 1985-03 Impact factor: 13.506

9. Antitumor activity of deoxyribonucleic acid fraction from Mycobacterium bovis BCG. I. Isolation, physicochemical characterization, and antitumor activity.

Authors: T Tokunaga; H Yamamoto; S Shimada; H Abe; T Fukuda; Y Fujisawa; Y Furutani; O Yano; T Kataoka; T Sudo
Journal: J Natl Cancer Inst Date: 1984-04 Impact factor: 13.506

10. Antitumor activity of synthetic oligonucleotides with sequences from cDNA encoding proteins of Mycobacterium bovis BCG.

Authors: T Kataoka; S Yamamoto; T Yamamoto; E Kuramoto; Y Kimura; O Yano; T Tokunaga
Journal: Jpn J Cancer Res Date: 1992-03

12 in total

Synthetic oligonucleotides with certain palindromes stimulate interferon production of human peripheral blood lymphocytes in vitro.

1. In vitro augmentation of natural killer activity of peripheral blood cells from cancer patients by a DNA fraction from Mycobacterium bovis BCG.

2. In vivo augmentation of natural killer cell activity with a deoxyribonucleic acid fraction of BCG.

3. DNA binding to human leukocytes. Evidence for a receptor-mediated association, internalization, and degradation of DNA.

4. Cloning and expression of the Mycobacterium bovis BCG gene for extracellular alpha antigen.

5. Mechanism of oligonucleotide uptake by cells: involvement of specific receptors?

6. Characterization, sequence determination, and immunogenicity of a 64-kilodalton protein of Mycobacterium bovis BCG expressed in escherichia coli K-12.

7. Unique palindromic sequences in synthetic oligonucleotides are required to induce IFN [correction of INF] and augment IFN-mediated [correction of INF] natural killer activity.

8. Antitumor activity of the DNA fraction from Mycobacterium bovis BCG. II. Effects on various syngeneic mouse tumors.

9. Antitumor activity of deoxyribonucleic acid fraction from Mycobacterium bovis BCG. I. Isolation, physicochemical characterization, and antitumor activity.

10. Antitumor activity of synthetic oligonucleotides with sequences from cDNA encoding proteins of Mycobacterium bovis BCG.

Review 1. The influence of base sequence on the immunostimulatory properties of DNA.

Review 2. Modulation of asthmatic response by immunostimulatory DNA sequences.

Review 3. The response of human B lymphocytes to oligodeoxynucleotides.

Review 4. Introduction to immunostimulatory DNA sequences.

Review 5. Activation of NK cell (human and mouse) by immunostimulatory DNA sequence.

Review 6. The antigenic properties of bacterial DNA in normal and aberrant immunity.

7. DNA activates human immune cells through a CpG sequence-dependent manner.

Review 8. Introduction: gene vaccination, current concepts and future directions.

9. Innate immune responses induced by CpG oligodeoxyribonucleotide stimulation of ovine blood mononuclear cells.

Review 10. Epithelial toll-like receptor 9 signaling in colorectal inflammation and cancer: clinico-pathogenic aspects.