Literature DB >> 7522929

Immunosuppressants and calcineurin inhibitors, cyclosporin A and FK506, reversibly inhibit epileptogenesis in amygdaloid kindled rat.

L J Moia1, H Matsui, G A de Barros, K Tomizawa, K Miyamoto, Y Kuwata, M Tokuda, T Itano, O Hatase.   

Abstract

Calcineurin (CaN) immunoreactivity and content increased markedly in kindled rat brain, and this increment was due to CaN in the membrane fraction. Investigation of the effects of cyclosporin A and FK506 (immunosuppressants which inhibit CaN activity in T lymphocytes) in the kindling phenomena showed that the kindling stage progression was reversibly blocked by these drugs. These findings suggest that calcineurin may play an essential role in acquiring epileptogenesis in kindling.

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Year:  1994        PMID： 7522929     DOI： 10.1016/0006-8993(94)91138-x

Source DB:  PubMed          Journal:  Brain Res        ISSN： 0006-8993            Impact factor:   3.252


  7 in total

1.  Traumatic Brain Injury Causes a Tacrolimus-Sensitive Increase in Non-Convulsive Seizures in a Rat Model of Post-Traumatic Epilepsy.

Authors:  John N Campbell; Anandh Gandhi; Baljinderjit Singh; Severn B Churn
Journal:  Int J Neurol Brain Disord       Date:  2014

2.  Hypoxia enhances high-voltage-activated calcium currents in rat primary cortical neurons via calcineurin.

Authors:  Kun Xiang; Damien Earl; Trisha Dwyer; Brian L Behrle; Elizabeth I Tietz; L John Greenfield
Journal:  Epilepsy Res       Date:  2012-01-13       Impact factor: 3.045

3.  A cellular mechanism for dendritic spine loss in the pilocarpine model of status epilepticus.

Authors:  Jonathan E Kurz; Bryan J Moore; Scott C Henderson; John N Campbell; Severn B Churn
Journal:  Epilepsia       Date:  2008-05-08       Impact factor: 5.864

4.  Prolonged infusion of inhibitors of calcineurin or L-type calcium channels does not block mossy fiber sprouting in a model of temporal lobe epilepsy.

Authors:  Elizabeth A Ingram; Izumi Toyoda; Xiling Wen; Paul S Buckmaster
Journal:  Epilepsia       Date:  2008-07-01       Impact factor: 5.864

Review 5.  Ascomycin and FK506: pharmacology and therapeutic potential as anticonvulsants and neuroprotectants.

Authors:  Germán Sierra-Paredes; Germán Sierra-Marcuño
Journal:  CNS Neurosci Ther       Date:  2008       Impact factor: 5.243

6.  The calcineurin inhibitor Ascomicin interferes with the early stage of the epileptogenic process induced by Latrunculin A microperfusion in rat hippocampus.

Authors:  Carmen Freire-Cobo; Germán Sierra-Paredes; Manuel Freire; Germán Sierra-Marcuño
Journal:  J Neuroimmune Pharmacol       Date:  2014-08-08       Impact factor: 4.147

7.  Glial Ca2+signaling links endocytosis to K+ buffering around neuronal somas to regulate excitability.

Authors:  Shirley Weiss; Jan E Melom; Kiel G Ormerod; Yao V Zhang; J Troy Littleton
Journal:  Elife       Date:  2019-04-26       Impact factor: 8.140
  7 in total

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