Purified protein products of rDNA technology expressed in animal cell culture.

During the past 7 years, 14 versions of 7 rDNA proteins have been licensed which are derived from animal cell culture expression systems. These medically useful products have included hormones, coagulation factors, enzymes and a vaccine. Aspects of the molecular complexity, manufacture, control and utilization of these products are discussed. In contrast to previous generations of biological production technology, the technology for production of rDNA-derived proteins in animal cells appears to be safe.