OBJECTIVE: To review timely research on childhood-onset schizophrenia in view of advances in biological research on, and neurodevelopmental theories of, the later-onset disorder. METHOD: Research issues are outlined including further clarification of ICD- and DSM-defined childhood schizophrenia, and differentiation from autism "spectrum" and other subtle, chronic developmental disorders. Key neurobiological advances are reviewed for which child studies are relevant and feasible. CONCLUSION: It is anticipated that narrowly defined childhood-onset schizophrenics will constitute a predominantly male population. A high rate of family illness or chromosomal and/or brain developmental abnormalities, which will be instructive regarding the pathophysiology of later-onset schizophrenia, is expected.
OBJECTIVE: To review timely research on childhood-onset schizophrenia in view of advances in biological research on, and neurodevelopmental theories of, the later-onset disorder. METHOD: Research issues are outlined including further clarification of ICD- and DSM-defined childhood schizophrenia, and differentiation from autism "spectrum" and other subtle, chronic developmental disorders. Key neurobiological advances are reviewed for which child studies are relevant and feasible. CONCLUSION: It is anticipated that narrowly defined childhood-onset schizophrenics will constitute a predominantly male population. A high rate of family illness or chromosomal and/or brain developmental abnormalities, which will be instructive regarding the pathophysiology of later-onset schizophrenia, is expected.
Authors: Brian Weisinger; Deanna Greenstein; Anand Mattai; Liv Clasen; Francois Lalonde; Sara Feldman; Rachel Miller; Julia W Tossell; Nora S Vyas; Reva Stidd; Christopher David; Nitin Gogtay Journal: Schizophr Bull Date: 2011-05-25 Impact factor: 9.306
Authors: Randal G Ross; Karen E Stevens; William R Proctor; Sherry Leonard; Michael A Kisley; Sharon K Hunter; Robert Freedman; Catherine E Adams Journal: J Child Psychol Psychiatry Date: 2009-11-18 Impact factor: 8.982
Authors: David Fraguas; María J de Castro; Oscar Medina; Mara Parellada; Dolores Moreno; Montserrat Graell; Jessica Merchán-Naranjo; Celso Arango Journal: Child Psychiatry Hum Dev Date: 2007-07-31