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Literature DB >> 7521855

Inactivation of bleomycin by an N-acetyltransferase in the bleomycin-producing strain Streptomyces verticillus.

M Sugiyama¹, T Kumagai, M Shionoya, E Kimura, J E Davies.

Abstract

Bleomycin-producing Streptomyces verticillus ATCC15003 possesses a bleomycin acetyltransferase which inactivates the drug in the presence of acetyl coenzyme A. The site of acylation in enzymically prepared acetylbleomycin A2 was determined by nuclear magnetic resonance analysis; the primary amino group of the beta-aminoalanine moiety of bleomycin was acetylated Acetylbleomycin A2 had no detectable antibacterial activity and did not induce in vitro DNA degradation.

Entities: Chemical Species

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Year: 1994 PMID： 7521855 DOI： 10.1111/j.1574-6968.1994.tb07079.x

Source DB: PubMed Journal: FEMS Microbiol Lett ISSN： 0378-1097 Impact factor: 2.742

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Cited

11 in total

1. Catalytic mechanism of bleomycin N-acetyltransferase proposed on the basis of its crystal structure.

Authors: Kosuke Oda; Yasuyuki Matoba; Masafumi Noda; Takanori Kumagai; Masanori Sugiyama
Journal: J Biol Chem Date: 2009-11-03 Impact factor: 5.157

Review 2. Structural biological study of self-resistance determinants in antibiotic-producing actinomycetes.

Authors: Masanori Sugiyama
Journal: J Antibiot (Tokyo) Date: 2015-04-15 Impact factor: 2.649

3. Crystal Structure of the Zorbamycin-Binding Protein ZbmA, the Primary Self-Resistance Element in Streptomyces flavoviridis ATCC21892.

Authors: Jeffrey D Rudolf; Lance Bigelow; Changsoo Chang; Marianne E Cuff; Jeremy R Lohman; Chin-Yuan Chang; Ming Ma; Dong Yang; Shonda Clancy; Gyorgy Babnigg; Andrzej Joachimiak; George N Phillips; Ben Shen
Journal: Biochemistry Date: 2015-11-05 Impact factor: 3.162

4. Characterization of BRP_MBL, the Bleomycin Resistance Protein Associated with the Carbapenemase NDM.

Authors: Laurent Dortet; Delphine Girlich; Anne-Laure Virlouvet; Laurent Poirel; Patrice Nordmann; Bogdan I Iorga; Thierry Naas
Journal: Antimicrob Agents Chemother Date: 2017-02-23 Impact factor: 5.191

5. 1H, 13C, and 15N assignment of a bleomycin resistance protein in its native form and in a complex with Zn2+ ligated bleomycin.

Authors: C Vanbelle; C Muhle-Goll; M H Remy; J M Masson; D Marion; B Brutscher
Journal: J Biomol NMR Date: 2000-10 Impact factor: 2.835

Inactivation of bleomycin by an N-acetyltransferase in the bleomycin-producing strain Streptomyces verticillus.

1. Catalytic mechanism of bleomycin N-acetyltransferase proposed on the basis of its crystal structure.

Review 2. Structural biological study of self-resistance determinants in antibiotic-producing actinomycetes.

3. Crystal Structure of the Zorbamycin-Binding Protein ZbmA, the Primary Self-Resistance Element in Streptomyces flavoviridis ATCC21892.

4. Characterization of BRP_MBL, the Bleomycin Resistance Protein Associated with the Carbapenemase NDM.

5. 1H, 13C, and 15N assignment of a bleomycin resistance protein in its native form and in a complex with Zn2+ ligated bleomycin.

6. Weapons in disguise--activating mechanisms and protecting group chemistry in nature.

7. ZmaR, a novel and widespread antibiotic resistance determinant that acetylates zwittermicin A.

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9. Bioconversion of 2,4-diamino-6-nitrotoluene to a novel metabolite under anoxic and aerobic conditions.

Review 10. Molecular insights on the biosynthesis of antitumour compounds by actinomycetes.