Literature DB >> 7521394

Five new cytotoxic T cell epitopes identified within Epstein-Barr virus nuclear antigen 3.

S R Burrows1, J Gardner, R Khanna, T Steward, D J Moss, S Rodda, A Suhrbier.   

Abstract

Epstein-Barr virus (EBV) CD8+ cytotoxic T lymphocyte (CTL) epitopes are currently being considered for inclusion into subunit vaccines. Here we describe the characterization of five new CTL epitopes within EBV nuclear antigen 3 (EBNA3), confirming EBNA3 as a major target for CTL recognition.

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Year:  1994        PMID： 7521394     DOI： 10.1099/0022-1317-75-9-2489

Source DB:  PubMed          Journal:  J Gen Virol        ISSN： 0022-1317            Impact factor:   3.891


  32 in total

1.  Identification of naturally processed and HLA-presented Epstein-Barr virus peptides recognized by CD4(+) or CD8(+) T lymphocytes from human blood.

Authors:  W Herr; E Ranieri; A Gambotto; L S Kierstead; A A Amoscato; L Gesualdo; W J Storkus
Journal:  Proc Natl Acad Sci U S A       Date:  1999-10-12       Impact factor: 11.205

2.  Type 2 cytokines predominate in the human CD4(+) T-lymphocyte response to Epstein-Barr virus nuclear antigen 1.

Authors:  P Steigerwald-Mullen; M G Kurilla; T J Braciale
Journal:  J Virol       Date:  2000-08       Impact factor: 5.103

3.  RelB nuclear translocation mediated by C-terminal activator regions of Epstein-Barr virus-encoded latent membrane protein 1 and its effect on antigen-presenting function in B cells.

Authors:  Saparna Pai; Brendan J O'Sullivan; Leanne Cooper; Ranjeny Thomas; Rajiv Khanna
Journal:  J Virol       Date:  2002-02       Impact factor: 5.103

Review 4.  The immunology of Epstein-Barr virus infection.

Authors:  D J Moss; S R Burrows; S L Silins; I Misko; R Khanna
Journal:  Philos Trans R Soc Lond B Biol Sci       Date:  2001-04-29       Impact factor: 6.237

5.  Hierarchy of Epstein-Barr virus-specific cytotoxic T-cell responses in individuals carrying different subtypes of an HLA allele: implications for epitope-based antiviral vaccines.

Authors:  R Khanna; S R Burrows; A Neisig; J Neefjes; D J Moss; S L Silins
Journal:  J Virol       Date:  1997-10       Impact factor: 5.103

6.  Minimal epitopes expressed in a recombinant polyepitope protein are processed and presented to CD8+ cytotoxic T cells: implications for vaccine design.

Authors:  S A Thomson; R Khanna; J Gardner; S R Burrows; B Coupar; D J Moss; A Suhrbier
Journal:  Proc Natl Acad Sci U S A       Date:  1995-06-20       Impact factor: 11.205

7.  Immediate-early transactivator Rta of Epstein-Barr virus (EBV) shows multiple epitopes recognized by EBV-specific cytotoxic T lymphocytes.

Authors:  S Pepperl; G Benninger-Döring; S Modrow; H Wolf; W Jilg
Journal:  J Virol       Date:  1998-11       Impact factor: 5.103

8.  Cytotoxic T-lymphocyte clones specific for an immunodominant epitope display discerning antagonistic response to naturally occurring Epstein-Barr virus variants.

Authors:  R Khanna; S R Burrows; S L Silins; D J Moss; L M Poulsen; J M Burrows
Journal:  J Virol       Date:  1996-10       Impact factor: 5.103

9.  Peptide transporter (TAP-1 and TAP-2)-independent endogenous processing of Epstein-Barr virus (EBV) latent membrane protein 2A: implications for cytotoxic T-lymphocyte control of EBV-associated malignancies.

Authors:  R Khanna; S R Burrows; D J Moss; S L Silins
Journal:  J Virol       Date:  1996-08       Impact factor: 5.103

10.  Unusually high frequency of Epstein-Barr virus genetic variants in Papua New Guinea that can escape cytotoxic T-cell recognition: implications for virus evolution.

Authors:  J M Burrows; S R Burrows; L M Poulsen; T B Sculley; D J Moss; R Khanna
Journal:  J Virol       Date:  1996-04       Impact factor: 5.103
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