Literature DB >> 7521139

Chloride secretion and function of serous and mucous cells of human airway glands.

W E Finkbeiner1, B Q Shen, J H Widdicombe.   

Abstract

Cells from the acini of human tracheal glands were grown in culture to produce confluent cell sheets of mucous or mixed seromucous phenotype. Levels of mediator-induced Cl secretion in mucous cells were 2-18% those of seromucous cells. Levels of the cystic fibrosis transmembrane conductance regulator (an apical membrane Cl channel) were also much less in mucous than in seromucous cells. These results suggest that serous cells are more important than mucous cells in providing the fluid component of gland secretions.

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Year:  1994        PMID： 7521139     DOI： 10.1152/ajplung.1994.267.2.L206

Source DB:  PubMed          Journal:  Am J Physiol        ISSN： 0002-9513


  9 in total

Review 1.  Status of gene therapy for cystic fibrosis lung disease.

Authors:  R C Boucher
Journal:  J Clin Invest       Date:  1999-02       Impact factor: 14.808

2.  Cystic fibrosis and the relationship between mucin and chloride secretion by cultures of human airway gland mucous cells.

Authors:  Walter E Finkbeiner; Lorna T Zlock; Masatoshi Morikawa; Anna Y Lao; Vijay Dasari; Jonathan H Widdicombe
Journal:  Am J Physiol Lung Cell Mol Physiol       Date:  2011-07-01       Impact factor: 5.464

3.  Fluid transport across cultures of human tracheal glands is altered in cystic fibrosis.

Authors:  C Jiang; W E Finkbeiner; J H Widdicombe; S S Miller
Journal:  J Physiol       Date:  1997-06-15       Impact factor: 5.182

4.  Na+ and Cl- conductances in airway epithelial cells: increased Na+ conductance in cystic fibrosis.

Authors:  K Kunzelmann; S Kathöfer; R Greger
Journal:  Pflugers Arch       Date:  1995-11       Impact factor: 3.657

5.  Submucosal gland secretions in airways from cystic fibrosis patients have normal [Na(+)] and pH but elevated viscosity.

Authors:  S Jayaraman; N S Joo; B Reitz; J J Wine; A S Verkman
Journal:  Proc Natl Acad Sci U S A       Date:  2001-06-26       Impact factor: 11.205

6.  Cultures of human tracheal gland cells of mucous or serous phenotype.

Authors:  Walter E Finkbeiner; Lorna T Zlock; Irum Mehdi; Jonathan H Widdicombe
Journal:  In Vitro Cell Dev Biol Anim       Date:  2009-12-09       Impact factor: 2.416

Review 7.  Gene therapy for cystic fibrosis.

Authors:  Christian Mueller; Terence R Flotte
Journal:  Clin Rev Allergy Immunol       Date:  2008-12       Impact factor: 8.667

8.  The amiloride-inhibitable Na+ conductance is reduced by the cystic fibrosis transmembrane conductance regulator in normal but not in cystic fibrosis airways.

Authors:  M Mall; M Bleich; R Greger; R Schreiber; K Kunzelmann
Journal:  J Clin Invest       Date:  1998-07-01       Impact factor: 14.808

9.  Effects of indacaterol on the LPS-evoked changes in fluid secretion rate and pH in swine tracheal membrane.

Authors:  Hidemi Aritake; Tsutomu Tamada; Koji Murakami; Shunichi Gamo; Masayuki Nara; Itsuro Kazama; Masakazu Ichinose; Hisatoshi Sugiura
Journal:  Pflugers Arch       Date:  2021-05-24       Impact factor: 3.657
  9 in total

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