Literature DB >> 7520938

Potent inhibitors of histamine release: polyhydroxylated sterols from the Okinawan soft coral Sinularia abrupta.

N Shoji1, A Umeyama, M Takei, S Arihara.   

Abstract

A new polyhydroxylated steroid (24-methylene-1 alpha, 3 beta, 11 alpha-trihydroxycholest-5-ene-18-oic acid-3-acetate, 1) and known related compounds (2-4) from the soft coral Sinularia abrupta have potently inhibited histamine release from rat peritoneal mast cells induced by anti-immunoglobulin E. The inhibitory effect of 1 was approximately 6500 times stronger than that of disodium cromoglycate, a well-known antiallergic drug.

Entities:  

Mesh：

Substances：

Year:  1994        PMID： 7520938     DOI： 10.1002/jps.2600830534

Source DB:  PubMed          Journal:  J Pharm Sci        ISSN： 0022-3549            Impact factor:   3.534


  3 in total

Review 1.  Role of dietary phospholipids and phytosterols in protection against peptic ulceration as shown by experiments on rats.

Authors:  Frank I Tovey
Journal:  World J Gastroenterol       Date:  2015-02-07       Impact factor: 5.742

2.  Sinulolides A-H, new cyclopentenone and butenolide derivatives from soft coral Sinularia sp.

Authors:  Bin Yang; Xiaoyi Wei; Jingxia Huang; Xiuping Lin; Juan Liu; Shengrong Liao; Junfeng Wang; Xuefeng Zhou; Lishu Wang; Yonghong Liu
Journal:  Mar Drugs       Date:  2014-10-23       Impact factor: 5.118

3.  Dietary Phytosterols Protective Against Peptic Ulceration.

Authors:  Frank I Tovey; Doga Capanoglu; G John Langley; Julie M Herniman; Serhat Bor; Omer Ozutemiz; Michael Hobsley; Karna Dev Bardhan; Bruno Linclau
Journal:  Gastroenterology Res       Date:  2011-07-20
  3 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.