Literature DB >> 7520871

The mammary factor MPBF is a prolactin-induced transcriptional regulator which binds to STAT factor recognition sites.

T G Burdon1, J Demmer, A J Clark, C J Watson.   

Abstract

Site-directed mutagenesis of the three binding sites for the mammary factor MPBF in the beta-lactoglobulin (BLG) promoter demonstrates that MPBF is a transcriptional activator of the BLG gene in mammary cells. MPBF requires phosphorylation on tyrosine for maximum binding activity and binds to GAS (interferon gamma-activation site) elements which are similar to the MPBF binding sites. Prolactin induces MPBF binding activity in CHO cells and is not antigenically related to Stat1 (p91) and Stat2 (p113), suggesting that this transcription factor is likely to be another member of the STAT family of cytokine/growth factor-induced transcription factors.

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Year:  1994        PMID： 7520871     DOI： 10.1016/0014-5793(94)00757-8

Source DB:  PubMed          Journal:  FEBS Lett        ISSN： 0014-5793            Impact factor:   4.124


  17 in total

Review 1.  Developing a mammary gland is a stat affair.

Authors:  L Hennighausen; G W Robinson; K U Wagner; X Liu
Journal:  J Mammary Gland Biol Neoplasia       Date:  1997-10       Impact factor: 2.673

Review 2.  Stat transcription factors in mammary gland development and tumorigenesis.

Authors:  C J Watson
Journal:  J Mammary Gland Biol Neoplasia       Date:  2001-01       Impact factor: 2.673

3.  Protein profile and alpha-lactalbumin concentration in the milk of standard and transgenic goats expressing recombinant human butyrylcholinesterase.

Authors:  H Baldassarre; M Schirm; J Deslauriers; C Turcotte; V Bordignon
Journal:  Transgenic Res       Date:  2009-03-19       Impact factor: 2.788

4.  The changing role of cell culture in the generation of transgenic livestock.

Authors:  C B Whitelaw; E Farini; J Webster
Journal:  Cytotechnology       Date:  1999-09       Impact factor: 2.058

5.  Extracellular matrix-dependent tissue-specific gene expression in mammary epithelial cells requires both physical and biochemical signal transduction.

Authors:  C D Roskelley; P Y Desprez; M J Bissell
Journal:  Proc Natl Acad Sci U S A       Date:  1994-12-20       Impact factor: 11.205

6.  Detection of endoplasmic reticulum stress markers and production enhancement treatments in transgenic goats expressing recombinant human butyrylcholinesterase.

Authors:  H Baldassarre; J Deslauriers; N Neveu; V Bordignon
Journal:  Transgenic Res       Date:  2011-02-22       Impact factor: 2.788

7.  Characterization of BCE-1, a transcriptional enhancer regulated by prolactin and extracellular matrix and modulated by the state of histone acetylation.

Authors:  C A Myers; C Schmidhauser; J Mellentin-Michelotti; G Fragoso; C D Roskelley; G Casperson; R Mossi; P Pujuguet; G Hager; M J Bissell
Journal:  Mol Cell Biol       Date:  1998-04       Impact factor: 4.272

Review 8.  Molecular mechanisms of hormone controlled gene expression in the breast.

Authors:  L Hennighausen
Journal:  Mol Biol Rep       Date:  1997-08       Impact factor: 2.316

9.  Study of polymorphisms in the promoter region of ovine β-lactoglobulin gene and phylogenetic analysis among the Valle del Belice breed and other sheep breeds considered as ancestors.

Authors:  S Mastrangelo; M T Sardina; V Riggio; B Portolano
Journal:  Mol Biol Rep       Date:  2011-05-13       Impact factor: 2.316

10.  Insulin, a key regulator of hormone responsive milk protein synthesis during lactogenesis in murine mammary explants.

Authors:  Karensa K Menzies; Heather J Lee; Christophe Lefèvre; Christopher J Ormandy; Keith L Macmillan; Kevin R Nicholas
Journal:  Funct Integr Genomics       Date:  2009-10-15       Impact factor: 3.410
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