Literature DB >> 7520655

[The determination of the antigenic determinant of protective monoclonal antibodies specific to the Francisella tularensis lipopolysaccharide].

V S Khlebnikov, I R Golovlev, N V Tokhtamysheva, S F Averin, D P Kulevatskiĭ, G K Grechko, A A Averina, S S Vetchinin.   

Abstract

F. tularensis lipopolysaccharide (LPS) was studied with the use of monoclonal antibodies (McAb) having protective properties. The binding site of these McAb (IgG2a) is localized on the O-chain of LPS. In contrast to LPS isolated from vaccine strain 15, LPS isolated from F. tularensis cells in the R-form has no O-chains and does not interact with McAb.

Entities:  

Mesh：

Substances：

Year:  1993        PMID： 7520655

Source DB:  PubMed          Journal:  Zh Mikrobiol Epidemiol Immunobiol        ISSN： 0372-9311


  4 in total

1.  Characterization of monoclonal antibodies to terminal and internal O-antigen epitopes of Francisella tularensis lipopolysaccharide.

Authors:  Marly I Roche; Zhaohua Lu; Julia H Hui; Jacqueline Sharon
Journal:  Hybridoma (Larchmt)       Date:  2011-02

2.  Protective B-cell epitopes of Francisella tularensis O-polysaccharide in a mouse model of respiratory tularaemia.

Authors:  Zhaohua Lu; Guillermo Madico; Marly I Roche; Qi Wang; Julia H Hui; Hillary M Perkins; Joseph Zaia; Catherine E Costello; Jacqueline Sharon
Journal:  Immunology       Date:  2012-07       Impact factor: 7.397

3.  Generation and characterization of hybridoma antibodies for immunotherapy of tularemia.

Authors:  Zhaohua Lu; Marly I Roche; Julia H Hui; Berkay Unal; Philip L Felgner; Sunita Gulati; Guillermo Madico; Jacqueline Sharon
Journal:  Immunol Lett       Date:  2007-08-08       Impact factor: 3.685

4.  The binding sites of monoclonal antibodies to the non-reducing end of Francisella tularensis O-antigen accommodate mainly the terminal saccharide.

Authors:  Zhaohua Lu; Michael J Rynkiewicz; Chiou-Ying Yang; Guillermo Madico; Hillary M Perkins; Qi Wang; Catherine E Costello; Joseph Zaia; Barbara A Seaton; Jacqueline Sharon
Journal:  Immunology       Date:  2013-11       Impact factor: 7.397
  4 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.