Literature DB >> 7520537

Increase by NO synthase inhibitors of acetylcholine release from guinea-pig myenteric plexus.

H Kilbinger1, D Wolf.   

Abstract

The effects of nitric oxide (NO) synthase inhibitors on the electrically evoked release of [3H]acetylcholine were studied in guinea-pig myenteric plexus preparations preincubated with [3H]choline. NG-monomethyl-L-arginine (EC50 5.3 mumol l-1) and NG-nitro-L-arginine (EC50 1.3 mumol l-1) concentration-dependently increased the evoked release of [3H]acetylcholine without affecting the basal outflow. The facilitatory effect of NG-mono-methyl-L-arginine was prevented by L-arginine but not by D-arginine. The results suggest that endogenous NO inhibits the depolarisation-evoked release of acetylcholine.

Entities:  

Mesh：

Substances：

Year:  1994        PMID： 7520537     DOI： 10.1007/bf00169145

Source DB:  PubMed          Journal:  Naunyn Schmiedebergs Arch Pharmacol        ISSN： 0028-1298            Impact factor:   3.000


  21 in total

1.  NG-nitro-L-arginine (N5-[imino(nitroamino)methyl]-L-ornithine) impairs endothelium-dependent dilations by inhibiting cytosolic nitric oxide synthesis from L-arginine.

Authors:  A Mülsch; R Busse
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1990 Jan-Feb       Impact factor: 3.000

2.  Effects of L-NG-nitro arginine on cholinergic transmission in the gastric muscle of the rabbit.

Authors:  M C Baccari; M Bertini; F Calamai
Journal:  Neuroreport       Date:  1993-09       Impact factor: 1.837

3.  Vasoactive intestinal peptide release and L-citrulline production from isolated ganglia of the myenteric plexus: evidence for regulation of vasoactive intestinal peptide release by nitric oxide.

Authors:  J R Grider; J G Jin
Journal:  Neuroscience       Date:  1993-05       Impact factor: 3.590

4.  A possible role of the L-arginine-nitric oxide pathway in the modulation of cholinergic transmission in the guinea-pig taenia coli.

Authors:  M A Knudsen; A Tøttrup
Journal:  Br J Pharmacol       Date:  1992-11       Impact factor: 8.739

5.  Influence of vasoactive intestinal polypeptide and NG-nitro-L-arginine methyl ester on cholinergic neurotransmission in the rat gastric fundus.

Authors:  R A Lefebvre; A De Vriese; G J Smits
Journal:  Eur J Pharmacol       Date:  1992-10-20       Impact factor: 4.432

6.  Nitric oxide releases acetylcholine in the basal forebrain.

Authors:  H Prast; A Philippu
Journal:  Eur J Pharmacol       Date:  1992-05-27       Impact factor: 4.432

7.  Modulation of cholinergic neural bronchoconstriction by endogenous nitric oxide and vasoactive intestinal peptide in human airways in vitro.

Authors:  J K Ward; M G Belvisi; A J Fox; M Miura; S Tadjkarimi; M H Yacoub; P J Barnes
Journal:  J Clin Invest       Date:  1993-08       Impact factor: 14.808

Review 8.  Nitric oxide as a mediator of nonadrenergic noncholinergic neurotransmission.

Authors:  K M Sanders; S M Ward
Journal:  Am J Physiol       Date:  1992-03

9.  The influence of L-NG-nitro-arginine on field stimulation induced contractions and acetylcholine release in guinea pig isolated tracheal smooth muscle.

Authors:  S R Brave; A J Hobbs; A Gibson; J F Tucker
Journal:  Biochem Biophys Res Commun       Date:  1991-09-16       Impact factor: 3.575

10.  Interaction of forskolin with the effect of atropine on [3H]acetylcholine secretion in guinea-pig ileum myenteric plexus.

Authors:  P Alberts; V R Ogren
Journal:  J Physiol       Date:  1988-01       Impact factor: 5.182
View more
  8 in total

1.  Facilitation and inhibition by capsaicin of cholinergic neurotransmission in the guinea-pig small intestine.

Authors:  Christian Geber; Christian F Mang; Heinz Kilbinger
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  2005-11-22       Impact factor: 3.000

2.  Functional evidence for NO-synthase activation by substance P through a mechanism not involving classical tachykinin receptors in guinea-pig ileum in vitro.

Authors:  R Garcia-Villar; C Dupuis; J P Martinolle; J Fioramonti; L Buéno
Journal:  Br J Pharmacol       Date:  1996-07       Impact factor: 8.739

3.  Neural mechanisms underlying migrating motor complex formation in mouse isolated colon.

Authors:  S M Brierley; K Nichols; D J Grasby; S A Waterman
Journal:  Br J Pharmacol       Date:  2001-01       Impact factor: 8.739

4.  Participation of nitric oxide in the relaxation of the rat gastric corpus.

Authors:  U Holzer-Petsche; R L Moser
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1996 Aug-Sep       Impact factor: 3.000

5.  Differential effects of nitric oxide donors on basal and electrically evoked release of acetylcholine from guinea-pig myenteric neurones.

Authors:  K Hebeiss; H Kilbinger
Journal:  Br J Pharmacol       Date:  1996-08       Impact factor: 8.739

6.  Characterization of nitrergic neurotransmission during short- and long-term electrical stimulation of the rabbit anococcygeus muscle.

Authors:  L Kasakov; S Cellek; S Moncada
Journal:  Br J Pharmacol       Date:  1995-08       Impact factor: 8.739

7.  Nitric oxide induces acetylcholine-mediated contractions in the guinea-pig small intestine.

Authors:  L Barthó; R Lefebvre
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1994-11       Impact factor: 3.000

8.  Tachykinergic neurotransmission is enhanced in duodenum from dystrophic (mdx) mice.

Authors:  Maria Grazia Zizzo; Flavia Mulè; Rosa Serio
Journal:  Br J Pharmacol       Date:  2005-06       Impact factor: 8.739
  8 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.