| Literature DB >> 7520355 |
T Yoshida1, K Ishimaru, H Sakamoto, J Yokota, S Hirohashi, K Igarashi, K Sudo, M Terada.
Abstract
The hst-1 transforming gene encodes a protein which belongs to the FGF family of growth factors. We showed previously that a human hst-1 protein produced in silkworm cells has in vitro mitogenic activity to vascular endothelial cells. Here we report effective synthesis of an unfused human hst-1 protein in E. coli and a potent in vivo angiogenic activity of this hst-1 protein by two in vivo assays for angiogenesis, chick chorioallantoic membrane assay and rat cornea assay. The NIH3T3 transformant transfected with the hst-1 gene appeared to develop a highly-vascularized tumor on nude mice. These data showed that the hst-1 protein has an angiogenic activity in vivo as well as in vitro.Entities:
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Year: 1994 PMID： 7520355 DOI： 10.1016/0304-3835(94)90328-x
Source DB: PubMed Journal: Cancer Lett ISSN： 0304-3835 Impact factor: 8.679