OBJECTIVE: Our purpose was to determine whether serum progesterone, with or without quantitative beta-human chorionic gonadotropin, is predictive of pregnancy outcome within the first 8 weeks of gestation in asymptomatic women. STUDY DESIGN: Asymptomatic patients at < 8 menstrual weeks' gestation were prospectively evaluated. The enrollment protocol included history, physical examination, ultrasonographic confirmation, and blood sample collection for beta-human chorionic gonadotropin and progesterone. The association between progesterone and beta-human chorionic gonadotropin values and pregnancy outcome was determined by logistic regression analysis. A receiver-operator characteristic curve was generated on the basis of the sensitivity and specificity of progesterone results. RESULTS: Seventy-four patients were evaluated in this study. The mean serum progesterone level for viable pregnancies was 22.1 ng/ml, which was significantly greater than that for the nonviable gestations, 10.1 ng/ml (p < 0.001). A single progesterone level was predictive of pregnancy outcome (p < 0.001). The probability of an abnormal pregnancy outcome with a serum progesterone level < or = 6 ng/ml was 81%. A single beta-human chorionic gonadotropin level did not contribute to the prediction of pregnancy outcome (p = 0.59). CONCLUSIONS: Serum progesterone alone, within the first 8 weeks of gestation, is predictive of pregnancy outcome.
OBJECTIVE: Our purpose was to determine whether serum progesterone, with or without quantitative beta-human chorionic gonadotropin, is predictive of pregnancy outcome within the first 8 weeks of gestation in asymptomatic women. STUDY DESIGN: Asymptomatic patients at < 8 menstrual weeks' gestation were prospectively evaluated. The enrollment protocol included history, physical examination, ultrasonographic confirmation, and blood sample collection for beta-human chorionic gonadotropin and progesterone. The association between progesterone and beta-human chorionic gonadotropin values and pregnancy outcome was determined by logistic regression analysis. A receiver-operator characteristic curve was generated on the basis of the sensitivity and specificity of progesterone results. RESULTS: Seventy-four patients were evaluated in this study. The mean serum progesterone level for viable pregnancies was 22.1 ng/ml, which was significantly greater than that for the nonviable gestations, 10.1 ng/ml (p < 0.001). A single progesterone level was predictive of pregnancy outcome (p < 0.001). The probability of an abnormal pregnancy outcome with a serum progesterone level < or = 6 ng/ml was 81%. A single beta-human chorionic gonadotropin level did not contribute to the prediction of pregnancy outcome (p = 0.59). CONCLUSIONS: Serum progesterone alone, within the first 8 weeks of gestation, is predictive of pregnancy outcome.
Authors: Chloe R McDonald; Andrea L Conroy; Joel L Gamble; Eszter Papp; Michael Hawkes; Peter Olwoch; Paul Natureeba; Moses Kamya; Michael Silverman; Deborah Cohan; Catherine A Koss; Grant Dorsey; Kevin C Kain; Lena Serghides Journal: Clin Infect Dis Date: 2018-01-18 Impact factor: 9.079
Authors: Mehmet A Osmanağaoğlu; S Caner Karahan; Turhan Aran; Süleyman Güven; Elif Turgut; Ahmet Menteşe; Hasan Bozkaya Journal: Int Sch Res Notices Date: 2014-07-01
Authors: Chee Wai Ku; John C Allen; Sze Min Lek; Ming Li Chia; Nguan Soon Tan; Thiam Chye Tan Journal: BMC Pregnancy Childbirth Date: 2018-09-05 Impact factor: 3.007